Key words Small-cell lung cancerMaintenancechemotherapyDose intensityStem-cell supportAs have many other chemosensitive tumors, small-cell lung cancer (SCLC) has a well-documented chemotherapy dose-response relationship. However, a relationship between dose and survival has not yet been established. ...
Further studies with these new drugs utilized in combination chemo therapeutic regimens are needed to define the role of these agents in the treatment of patients with SCLC.doi:10.1016/S0169-5002(10)80018-2DavidS.EttingerLung CancerEttinger DS. New drugs for treating small cell lung cancer. ...
Small cell lung cancer (SCLC) represents 15% of lung cancers and is characterized by early dissemination, development of chemoresistance and a poor prognosis. A host of diverse drugs failed invariably and its mechanisms of global chemoresistance have not been characterized so far. SCLC represents the...
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
Molecular basis of chemo-resistance and synergism with immunotherapy Cytotoxic drugs can induce an immunogenic cell death, leading to the generation of molecular signals that pro- mote the uptake of dying cancer cells' debris by antigen presenting cells (APC), and the cross-presentation of tumor ...
CHEMOIMMUNOTHERAPYL1210The replication cycle of human immunodeficiency virus type 1 (HIV-1) consists of four distinct stages, each of which can be targeted for specific antiviral chemotherapy. The stages are (1) the attachment of virus to the CD4 receptor at the cell surface; (2) the un...
1. Lung cancer is the leader malignancy worldwide (18% of the total cancer deaths), and non-small cell lung cancer (NSCLC) represents its most common subtype [1]. According to the SEER database, mo...
Combined small-cell carcinoma Both include many types of cells that grow and spread in different ways. They’re named according to what the cells look like under a microscope. Small-cell lung cancer differs from non-small-cell lung cancer in some key ways. Small-cell lung cancer: ...
Radiation Oncology (2020) 15:167 https://doi.org/10.1186/s13014-020-01595-3 REVIEW Open Access Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy Lukas Käsmann1,2,3†, Chukwuka ...
LBA5 - Efficacy and safety of nivolumab (nivo) monotherapy versus chemotherapy (chemo) in recurrent small cell lung cancer (SCLC): results from checkmate 331 Ann. Oncol., 29 (suppl_10) (2018), p. 43 Google Scholar [32] P.A. Ott, E. Elez, S. Hiret, Kim D.W., A. Morosky, S...