Desmoplastic small round-cell tumor is an uncommon, highly aggressive tumor with a predilection for pediatric age groups and young adults. It is very unusual in the elderly population. Although Agent Orange has been associated with soft-tissue sarcoma, an association with desmoplastic small round-cel...
The role of precision medicine in advanced non-small cell lung cancer (NSCLC) has been continuously increasing in the latest years. The path to achieve complete molecular information is certainly long and challenging, as it is affected by the evolving and ever-changing nature of the neoplastic ph...
NON-small-cell lung carcinomaPHLOROTANNINSCELLULAR signal transductionCANCER cell proliferationCANCER cell migrationCADHERINSTUMOR suppressor proteinsACRIDINE orangeNon‐small–cell lung cancer (NSCLC) is one of the most prevalent type of lung cancers with an increased mortality rate in both developed...
Question Is there an association between broad-based genomic sequencing and better survival compared with routine genomic testing (EGFR/ALK alterations only) among patients with advanced non–small cell lung cancer treated in the community oncology setting? Findings In this retrospective cohort study that...
Given that the MYC proto-oncogene is deregulated in many cancers [42,43], it remains to be seen if MYC drives BC200 expression in other cancers besides non-small cell lung cancer (NSCLC) [27]. Like other promoters, the specific transcription factors that regulate BC200 transcription at an...
The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 5000 targeted agent combinations across 81 non-small cell lung cancer cell lines. Our analysis reveals a profound heterogeneity of response across the tumor models. Notably, ...
To discuss the optimal treatment modality for inoperable locally advanced Non-Small Cell Lung Cancer patients with poor physical status, impaired cardio-pulmonary function, and negative driver genes, and provide clinical evidence. Retrospective analysis
PURPOSE: We propose ERRP(EGF-Receptor Related Peptide), a novel endogenous-secretory-protein and negative-regulator of EGFR, as a potential dual-receptor-specific target-based-agent. We hypothesize that ERRP inhibits proliferation of non-small-cell-lung-cancer(NSCLC) cells by blocking both EGFR and...
Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) often develop resistance to current standard third-generation EGFR tyrosine kinase inhibitors (TKIs); no targeted treatments are approved in the osimertinib-
Validation of TNIK association with IPF using the single-cell gene expression dataset from unaffected lung and patients with IPF53demonstrates thatTNIKexpression in cytotoxic T cells, myofibroblasts and club cells is higher in fibrotic tissue than in unaffected controls (Extended Data Fig.2d–f). Th...