Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. Current treatments are insufficient in improving the prognosis of lung cancer patients with comorbid idiopathic
Worldwide, tobacco smoking is the principal lifestyle exposure that causes cancer, exerting carcinogenicity through >60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small-cell lung cancer cell line, NCI-H209, to explore the mutational burden ...
NON-small-cell lung carcinomaPHLOROTANNINSCELLULAR signal transductionCANCER cell proliferationCANCER cell migrationCADHERINSTUMOR suppressor proteinsACRIDINE orangeNon‐small–cell lung cancer (NSCLC) is one of the most prevalent type of lung cancers with an increased mortality rate in both developed and...
Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor prognosis. Current treatments are insufficient in improving the prognosis of lung cancer patients with comorbid idiopathic pulmonary fibrosis (IPF-LC). Senescent fibro
small cell lung cancer cell lines. Our analysis reveals a profound heterogeneity of response across the tumor models. Notably, combinations very rarely result in a strong gain in efficacy over the range of response observable with single agents. Importantly, gain of activity over single agents is ...
Merck Provides Update on Phase 3 KEYLYNK-006 Trial Evaluating KEYTRUDA® (pembrolizumab) Plus Maintenance LYNPARZA® (olaparib) for Certain Patients With Metastatic Nonsquamous Non-Small Cell Lung Cancer Save March...
Locally Advanced Resectable Gastric Cancer JAMA Oncology Research April 17, 2025 Management of EGFR-Variant and ALK-Positive Non–Small Cell Lung Cancer Brain Metastasis JAMA Oncology Opinion April 3, 2025 Can Knowledge From Treating Chronic Myeloid Leukemia Inform Therapy of EGFR -Mutant Lung ...
The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 5000 targeted agent combinations across 81 non-small cell lung cancer cell lines. Our analysis reveals a profound heterogeneity of response across the tumor models. Notably, ...
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lung. Here, we reported that oncoprotein cancer
British Journal of Cancer www.nature.com/bjc ARTICLE OPEN Cellular and Molecular Biology Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer SJ Cutty1, FA Hughes2,3, P. Ortega-Prieto3, S. Desai4, P. Thomas2, LV Fets3, M. Secrier 5 and AR Barr 1,3 ✉ © ...