Liu, Y. (2018) Small cell lung cancer transformation from EGFR-mutated lung adenocarcinoma: a case report and literatures review. Cancer Biol. Ther. 19, 445-449LIU Y. Small cell lung cancer transformation from EGFR-mutated lung adenocarcinoma: acase report and literatures review[J]. Cancer ...
cell carcinoma has been dropped from the new WHO classification, and the only subtype of SCLC is combined SCLC. Less than 10% of SCLCs are admixed with non–small cell lung carcinoma (NSCLC) components (with large cells 4% to 6%, 1% to 3% with adenocarcinoma or squamous cell carcinoma)...
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts Article Open access 19 April 2022 Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype Article 25...
The NSCLC component can be represented by AC, SCC, and large cell neuroendocrine carcinoma (LCNEC). Most of the cases are SCLC with either adenocarcinoma or SCC component; however there are also rare case reports of up to 3–4 different morphologic tumors which have been reported [4], [5]...
肺癌分为小细胞肺癌(small cell lung cancer,SCLC)和非小细胞肺癌(non-small cell lung cancer,NSCLC),其中NSCLC占约85%,5年生存率只有不到20% [1,2] 。由于肺癌的早期临床症状不明显,诊断时多为中晚期,极大地提高了诊疗的难度和患者的死亡率。虽然临床常采用癌胚抗原(carcinoembryonic antigen,CEA)、神经元...
Small cell lung cancer (SCLC) represents 15% of lung cancers and is characterized by early dissemination, development of chemoresistance and a poor prognosis. A host of diverse drugs failed invariably and its mechanisms of global chemoresistance have not been characterized so far. SCLC represents the...
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.What are the subtypes of NSCLC?Squamous cell carcinoma is found in cells that line the airways of the lungs. It is usually found in the middle of the lung. Adenocarcinoma is found in cells that produce mucus. It...
Adenocarcinoma: This is the most common type. It usually spreads more slowly than others, and it's more likely to be found earlier. It's often linked to a history of smoking, but it is also the most common type of lung cancer seen in nonsmokers. ...
et al. Immune surveillance in clinical regression of preinvasive squamous cell lung cancer. Cancer Discov. 10, 1489–1499 (2020). Article CAS PubMed PubMed Central Google Scholar Hu, X. et al. Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma. ...
We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before ...