A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol. Ther. 22, 1254-65, doi:10.1038/mt.2014.59 (2014).Lee JJ, Kim H J, Yang CS, et a
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Three groups, including ours, have recently shown, however, that CA-170 is not a direct PD-L1-binder, which was evidenced in several independent biophysical and cell-based assays.21., 22., 23. The PD-1/PD-L1 interface is a challenging target due to its large, flat, and hydrophobic ...
Binder A, Ali A, Chawla R, Aziz HA, Abbate A, Jovin IS. Myocardial protection from ischemia-reperfusion injury post coronary revascularization. Expert Rev Cardiovasc Ther. 2015;13(9):1045–57. Article CAS PubMed Google Scholar Wu P, Yu S, Wang J, Zou S, Yao DS, Xiaochen Y. Global...
Fine diamond particles, with grain size of several tens of nanometres, are strongly and directly bonded without a binder under ultra-high-pressure and ultra-high-temperature environments creating nano-polycrystalline diamond. Although it has higher hardness than single-crystal diamond, it lacks the cl...
Here, we present the development of a high-affinity protein binder, termed repebody, which effectively suppresses non–small cell lung cancer in vivo by blocking the IL-6/STAT3 signaling. We selected a repebody that prevents human IL-6 (hIL-6) from binding to its receptor by a competitive...
AM is further classified based on the technology employed to create 3D structures, including techniques such as material extrusion, powder bed fusion [16], VAT photopolymerization, material jetting, binder jetting, sheet lamination, directed energy deposition, and more [17]. They all consist of ...
Binder, H. & Schumacher, M. Comment on 'Network-constrained regularization and variable selection for analysis of genomic data'. Bioinformatics 24, 2566–2568; author reply 2569, doi: 10.1093/bioinformatics/btn412 (2008). 55. Wang, M. et al. LegumeGRN: a gene regulatory network prediction ...