"I've been living with depression and anxiety for about half my life now," Josh said. "The fact that this was only a minute amount of [LSD], it seemed like a good way of trying something out." Josh said it wasn't too hard to secure liquid LSD from "a friend of a friend" in...
We have previously shown that lysine-specific demethylase 1A (KDM1A/LSD1) governs the differentiation of intestinal epithelial secretory cells, including Paneth and goblet cells15,16,17. In our previous studies, we used aVillin-Cre mouse strain that had 10-40% incomplete recombination27, which th...
Article https://doi.org/10.1038/s41467-024-47815-2 LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model Received: 10 September 2023 Accepted: 12 April 2024 Check for updates Alberto Díez-Sánchez 1 , Håvard...
B Enrichment of neuronal and NE HOMER transcription factor-binding DNA motifs in ATAC-seq peaks lost after treatment with FHD-286 (100 nM, 14 days). The percentage indicates the amount of target sequences with motif. C Genomic localization of lost and gained accessible sites upon FHD-286 ...
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy ArticleOpen access03 January 2025 Introduction Protein modification via neddylation regulates the stability, activity, or function of substrate proteins by covalently attaching a ubiquitin-like peptide NEDD8 (...
In these experiments, BC200 is primarily present in the cytoplasm; however, it should be pointed out that there is a small, but detectable amount of BC200 in the nuclear fraction as well [28,30]. In an alternative approach using an antibody directed against BC200 RNA, Shin et al. (...
The percentage indicates the amount of target sequences with motif. C Genomic localization of lost and gained accessible sites upon FHD-286 treatment in H82 and H146 cells. D ATACseq genome tracks of NEUROD1, SYP and CHGA in H82 and H146 cells after treatment with FHD-286. Peaks with...
The small Vacuum Pipette is equipped with replaceable batteries and is specially designed for flexible handling of small amounts of liquid. It has one-button control, simple operation and wide application. Features and advantages 1. Standard 1L collection ...
The amount of TGF-β1 secreted by H1975 cells increased after stimulation with almonertinib (Fig. 2C). Furthermore, the secretion of TGF-β1 in H1975 cells also increased with increasing almonertinib concentration. In addition, H1975 cells themselves do not secrete a small amount of TGF-...
efficiency and automaticity of high-throughput screening and the large amount of ncRNAs and small-molecular compounds, this technology is more suitable for the rapid screening of small-molecular compounds that regulate ncRNAs. Notably, screening models are an important part of the overall high-throughpu...