We found that SMAD5-AS1 was down-regulated in DLBCL tissues and cell lines. Functionally, SMAD5-AS1 downregulation promoted cell proliferation in vitro and in vivo, whereas SMAD5-AS1 overexpression could lead to the opposite effects in vitro and in vivo. Bioinformatics analysis and luciferase ...
Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC Chen-Chen Zhao, Yang Jiao, Yi-Yin Zhang, Jie Ning, Yi-Ruo Zhang, Jing Xu, Wei Wei & Gu Kang-Sheng Cell Death &...
英文名字 Recombinant Human SMAD5 antisense gene protein 1 (SMAD5-AS1) 供应商 MyBioSource 产品货号 MBS1307931 产品报价 ￥询价/0.02mg(E-Coli) ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话...
长链非编码RNA SMAD5‑AS1的siRNA在卵巢癌治疗中的应用刘倩肖磊刘辉车德红
食管癌增殖目的观察长链非编码核糖核酸(LncRNA)信号传导蛋白Sma和Mad相关蛋白同源物5(SMAD5)反义核糖核酸1(SMAD5AS1)干扰对人食管癌细胞株Eca109增殖的影响,并初步探讨可能的机制.方法取人食管癌细胞株Eca109培养传代,分别转染SMAD5AS1 siRNA沉默质粒,阴性对照质粒,并记为siRNA1组,siRNA阴性对照组,另取未转染细胞...
本发明公开了一种长链非编码RNA(long noncoding RNA,lncRNA)SMAD5AS1的siRNA在卵巢癌治疗中的应用.本发明通过设计并合成特异靶向抑制SMAD5AS1的siRNA序列,将其转染到卵巢癌细胞株中,证实抑制SMAD5AS1表达可显著抑制卵巢癌细胞的增殖,迁移与侵袭能力.本发明为卵巢癌的治疗提供了新方法和新的药物研发方向.刘倩...
SMAD5‐AS1 silencing or miR‐106a‐5p elevation inhibited tumorigenesis in nude mice. Taken together, SMAD5‐AS1 silencing suppressed EMT, cell proliferation, migration, and invasion in NPC by elevating miR‐106a‐5p to down‐regulate SMAD5, which provided a novel therapeutic target for NPC ...
本发明公开了一种长链非编码RNA(long noncoding RNA,lncRNA)SMAD5AS1的siRNA在卵巢癌治疗中的应用.本发明通过设计并合成特异靶向抑制SMAD5AS1的siRNA序列,将其转染到卵巢癌细胞株中,证实抑制SMAD5AS1表达可显著抑制卵巢癌细胞的增殖,迁移与侵袭能力.本发明为卵巢癌的治疗提供了新方法和新的药物研发方向.刘倩...
RNA pulldown assays and RNA immunoprecipitation were used to prove the interaction between ARHGAP5-AS1 and SMAD7. Western blot and immunofluorescence imaging were used to examine the protein levels. Dual luciferase reporter assays were performed to evaluate the activation of TGF-尾 signaling. Results...
lnc-FOXD3-AS1和SMAD1/5/8的表达水平都显著降低(均P<0.05),另外SMAD1/5/8的磷酸化水平明显降低(P<0.05).与pcDNA-null+IDA组比,pcDNA-FOXD3-AS1+IDA组的肝脏组织和血清中铁含量明显增加(均P<0.05),且Hepcidin,lnc-FOXD3-AS1和SMAD1/5/8的表达水平都显著升高(均P<0.05),另外SMAD1/5/8的磷酸化水平...