In turn, TGF‐β signaling forms a positive feedback loop with PCAT7 via SMAD3/SP1 complex‐induced PCAT7 upregulation. Finally, the clinical positive correlation between PCAT7 and TGFBR1 and TGF‐β signaling activity, and the negative association with miR‐324‐5p are further demonstrated ...
The overexpression of Sp1 caused further increase in COL1A2 promoter activity stimulated by TGF-beta in normal fibroblasts, but did not change COL1A2 promoter activity in the presence of TGF-beta in SSc fibroblasts. The combined overexpression of Smad3 and Sp1 significantly enhanced TGF-beta ...
increasetheexpressionofPA1.1 andcollagenI. [Keywords] TGF[~I;transcriptionalfactor;collagenI;RLF [摘要] 目的:检测转化生长因子131(T(;FI31)对大鼠肺成 纤维细胞(RLF)中转录因子SP1、AP1和Smad3一Smad4活性 的影响并探讨其意义。方法:进行大鼠肺成纤维细胞的原代 分离培养,应用10 LTGFIM进行处理,通过凝胶...
Canonical Smad3 signaling and ERK/Sp1 pathways mediate TGF-β-induced EGFR upregulation, and the enhancement of migration and invasion ability of breast cancer cells.Conclusions: TGF-β transactivates EGFR signaling by upregulating the EGFR expression in breast cancer cells. Our findings provided ...
3E, F). Furthermore, treatment with NEAT1 overexpressed exosomes promoted the expression levels of collagen I, α-SMA, fibronectin, Sp1, TGF-β1, phosphorylated-Smad2 and phosphorylated-Smad3 in LX-2 cells (Fig. 3G). However, treatment with NEAT1-depleted exosomes exerted the opposite effects...
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SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β.. Cordova G,Rochard A,Riquelme-Guzman C et al. Journal of Cellular Biochemistry . 2015...
Sp1 and Smad3 are required for high glucose-induced p21(WAF1) gene transcription in LLC-PK1 cells. J Cell Biochem. 2007; 102 :1190–1201. [ PubMed ]Chuang TD, Guh JY, Chiou SJ, Chen HC, Hung WC, Chuang LY. Sp1 and smad3 are required for high glucose-induced p21(waf1) gene ...
(typeⅠplasminogenactivatorinhibitor,PAIⅠ)的表达变化.结果正常RLF中AP1和Smad3Smad4形成弱阻滞条带,SP1无阻滞条带形成,3,5和8Gyγ射线照射后,3种转录因子所形成的阻滞条带明显增强,PAIⅠ和Ⅰ型胶原的表达增多.结论一定剂量γ射线能促进大鼠肺成纤维细胞中转录因子SP1,AP1和Smad3Smad4的活化...
Disruption of Smad7 Promotes ANG II-Mediated Renal Inflammation and Fibrosis via Sp1-TGF-β/Smad3-NF.κB-Dependent Mechanisms in Mice. Liu Guan-Xian,Li You-Qi,Huang Xiao R,Wei Lihua,Chen Hai-Yong,Shi Yong-Jun,Heuchel Rainer L,Lan Hui Y. PloS one . 2013...