DefinitionDefinitionSBE; Was initially defined by a consensus sequence of two inverted repeats of GTCT. More recent data suggest that a single GNCN repeat may also be sufficient for Smad-DNA binding.Springer Berlin HeidelbergEncyclopedia of Cancer...
DNA-affinity precipitation analysis revealed that c-Ski enhances the binding of Smad2 and 4, and to a lesser extent Smad3, to both CAGA and TGF-1 inhibitory element probes. A c-Ski mutant, which is unable to interact with Smad4, failed to enhance the binding of Smad complex on these ...
DNA-affinity precipitation analysis revealed that c-Ski enhances the binding of Smad2 and 4, and to a lesser extent Smad3, to both CAGA and TGF-1 inhibitory element probes. A c-Ski mutant, which is unable to interact with Smad4, failed to enhance the binding of Smad complex on these ...
Here we report the identification of Smad Binding Elements (SBEs) composed of the sequence CAGACA in the promoter of theJunB gene, an immediate early gene that is potently induced by TGF-β, activin, and bone morphogenetic protein (BMP) 2. TwoJunB SBEs are arranged as an inverted repeat ...
Similar results were observed with region −387/−264 of the mGnRHR gene promoter, although the magnitude of the response to GnRH agonist was greater, because this region contains both the −387/−308 region of interest as well as the previously described bipartite GnRH-response element,...
Smad3 and Smad4 are incorporated into a TGF-beta-inducible complex formed on this element following TGF-beta stimulation of human hepatoma cells. Both Smad3 and Smad4 bind directly to this TGF-beta-responsive element through their conserved MH1 domains. These results indicate that Smad3 and ...
Also provided are methods for using the Smad binding elements in methods of screening for compounds which bind the Smad binding element and in methods for modulating the binding of Smad proteins to Smad binding elements, e.g. to modulate TGF beta signal transduction. Further, the identification ...
Also provided are methods for using the Smad binding elements in methods of screening for compounds which bind the Smad binding element and in methods for modulating the binding of Smad proteins to Smad binding elements, e.g. to modulate TGFβ signal transduction. Further, the identification of ...
Also provided are methods for using the Smad binding elements in methods of screening for compounds which bind the Smad binding element and in methods for modulating the binding of Smad proteins to Smad binding elements, e.g. to modulate TGFβ signal transduction. Further, the identification of ...
Smad Binding Elementdoi:10.1007/978-3-642-16483-5_5362SBE; was initially defined by a consensus sequence of two inverted repeats of GTCT. More recent data suggest that a single GNCN repeat may also be sufficient for Smad-DNA binding. Due to the low...Springer Berlin Heidelberg...