Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects primarily women and is characterized by clinical diversity and a number of immunological abnormalities, notably the development of autoantibodies targeting the structures of
In reference to the control group, young patients with SLE had higher prevalence of chronic kidney disease (29.9% vs 5.1%; SMD = 0.7), hypertension (45.9% vs 13.2%; SMD = 0.8) and hypercoagulability (7.6% vs 0.5%; SMD = 0.4). As the population ages the difference in prevalence of ...
Disease Systemic Lupus Erythematosus Biosafety Level 1 Storage Liquid Nitrogen Product Type Blood Products Description Systemic Lupus Erythematosus (SLE) peripheral blood plasma is obtained by centrifugation of the SLE PB. This product has a diminished number of cells and platelets. Fresh SLE PB ...
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well as the contribution of disease-induced cellular abnormalities, remain largely unexplored. In this study, we con...
Download: Download full-size image Fig. 1. Summary of altered soluble mediators in SLE patients associated with heightened clinical disease activity and risk of imminent clinical disease flare. Inflammatory mediators significantly higher in SLE patients with impending disease flare (compared to NF/SNF ...
Systemic lupus erythematosus(SLE) is a chronic sys- temic autoimmune disease. There are different regimens for maintenance therapy of the disease. Corticosteroids play a key role in control of SLE patients' symptoms. As previous studies showed, there is a relationship between steroid use and ...
Full size table In our cohort, patients with serious infections were likely to have excess hospitalization of 2.34 times compared to those without. SLE is a chronic disease that requires lifelong therapy. Hospitalization significantly adds to the economic burden of the disease and accounts for the ...
T-lymphocyte subpopulation in untreated SLE. Variations with disease activity. Arthritis Rheum 1977; 20:1169-73.Rivero SJ, Llorente L, Diaz-Jouanen E, Alarcon- Segovia D: T-lymphocyte subpopulation in untreated SLE: variations with disease activity. Arthritis Rheum 20: 1169-1 173, 1977...
full, sustained target inhibition and was well tolerated in Phase 1 studies of healthy volunteers. The promising data to date for ESK-001 enables us to explore optimal dosing to drive efficacy, with the ultimate goal of achieving a best-in...
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by circulating autoantibodies and the formation of immune complexes. In these responses, the selecting self-antigens likely derive from the remains of dead and dying cells, as well as from disturbances in clearance. Du...