These studies provide new insights into the expression of MPs during SLE and demonstrate that, regardless of PS expression and phenotype, MPs occur in the blood of patients at levels 2 to 10 times greater than those of controls. In our studies, PS−MPs were twice as common than PS+MPs i...
used whole blood transcriptional profiling to identify seven transcriptionally distinct groups in a paediatric SLE population [2]. A number of studies have also identified autoantibody clusters in SLE, again reflecting the immunopathological heterogeneity within this patient group [3, 4]. Although a ...
The APS was defined according to Miyakis et al., with the exception that not all aPL tests were performed within five years of the clin- ical event54. On the morning of clinical assessment blood samples were drawn into citrated tubes after overnight fasting and centrifuged within 1 hour ...
4.3. Determination of MIF and P-gp Serum Levels On the same day as their clinical evaluation, blood samples were collected from all SLE patients as well as the individuals included in the reference group. Samples were taken by trained staff in the early hours of the morning with 8 h of ...