DepressionSerotoninSLC6A4 gene5HTTLPR polymorphismThe serotonin transporter proteinBackground The serotonin transporter (5HTT) is a protein locating on the presynaptic neuron membrane. The genes coding for 5HTT has 6 separate families, of which, SLC6A4. Polymorphism in the promoter region of SLC6A4...
In addition, eight SNPs in SLC6A4 and one haplotype Molecular Psychiatry 1116 Sequence variations of seven genes: pharmacogenetics of depression C Dong et al Table 6 Haplotypes associated with relative reduction of HAM-D21 score after 8-week antidepressant treatment Medication Gene Block no. ...
A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein,1 was recently reported to affect protein expression and to be associated with measures of anxiety and depression2 and with autism (using a family-controlled transmission disequilibrium test (TDT) design).3 SLC6A4...
Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are ...
Genetic polymorphism of theSLC6A4gene is associated with several behavioral disorders, including depression. Since studying the total nonsynonymous single nucleotide polymorphisms (nsSNPs) of theSLC6A4gene at the population level is a difficult task, we aim to utilizein silicoapproach to detect the ...
Relationships between polymorphisms and specific outcomes varied during the neonatal period, suggesting that beyond apparent gene-medication interactions, multiple mechanisms contribute to adverse neonatal outcomes following prenatal SRI exposure.doi:10.1038/sj.mp.4002007...
Evidence for epistasis between SLC6A4 and a chromosome 4 11 12 13 gene as risk factors in major depression. American Journal of Medical Genetics Part B: Neuropsychiatric 14 15 Genetics. 2010;153B(1):321-2. 16 17 13. Sewell WH. As We Age : The Wisconsin Longitudinal Study, 1957-2001:...
Neff CD, Abkevich V, Potter J, Riley R, Shattuck D, Katz DA (2009) Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression. Amer J Med Genet Part B Neuropsych Genet, published online (27 May 2009)...
Cervilla JA,Rivera M,Molina E,et al.The5-HTTLPR s/s geno-type at the serotonin transporter gene(SLC6A4)increases the risk for depression in a large cohort of primary care attendees:the PREDICT-gene study. Am J Med Genet B Neuropsychiatr Genet . 2006...
A polymorphism in the promoter region of the gene (SLC6A4) encoding this protein, was recently reported to affect protein expression and to be associated with measures of anxiety and depression and with autism (using a family-controlled transmission disequilibrium test (TDT) design). SLC6A4 ...