SLC1A5 variant (SLC1A5_var) is identified as a mitochondrial glutamine transporter in cancer cells recently. However, the role of SLC1A5_var in Parkinson's disease (PD) is completely unknown. Here, we found the significant downregulation of SLC1A5_var in astrocytes and midbrain of mice ...
SLC1A5var is up-regulated by ATF4 binding to an AARE-like sequence on its promoter.SLC1A5var knockdown decreases glucose depletion-induced cell death.Reducing SLC1A5var has promising effects against TNBC cancer progression.SLC1A5var reprograms metabolism to enhance glucose depletion-induced cell death...