Many twin and adoption studies have shown that ADHD symptoms in children are highly heritable, with about 76% contribution of heritable factors to phenotypic variance (Faraone et al, 2005). Although the heritability of the adult form of ADHD has not been formally established, the contribution of...
To further illustrate the mechanism of SLC15A4-mediated TASL recruitment and investigate conformational changes associated with TASL engagement, we next resolved the structure of apo SLC15A4. Human full-length SLC15A4 was overexpressed in mammalian cells using a twin-strep-tag and subsequently reconsti...