With CDN 212 billion (USD 159 billion) in combined assets under management as of March 31, 2019, SLC Management provides its more than 1000 institutional clients with a full range of yield-oriented investment solutions across public and private fixed income asset classes as well as global real ...
Full size table CHED familial case 1 Three siblings presented with a CHED clinical phenotype in this consanguineous family (F1). They showed varying degrees of corneal clouding. All three cases underwent DSAEK surgery to manage their corneal dystrophy. The parents and the fourth sibling were unaffe...
Feeblin/C5 is indicated in yellow. Full size image Discussion This study presents the discovery of a compound with an unusual mechanism of action: stabilization of a conformational switch within an MFS fold protein (SLC15A4) that is incompatible with interaction with an effector protein (TASL), ...
Full size image Loss of SLC27A5 enhances the resistance of HCC cells to sorafenib Since the low expression of SLC27A5 in sorafenib-resistant hepatoma cells, we sought to focus on analyzing whether SLC27A5 is functionally involved in sorafenib resistance. Thus next, SK-Hep1 and PLC/PRF/5 wer...
Full size image Tiam1 accelerates the proliferation of PC cells in vitro and in vivo WB analysis showed that Tiam1 was expressed in Patu8988, MIAPaca-2, Bxpc-3, and Panc-1 cell lines, with Bxpc-3 with significantly high expression and MIAPaca-2 with significantly low expression. Therefore...
3A. JWJGC significantly reduced ROS levels in the synovium. Furthermore, JWJGC decreased the MDA activity (Fig. 3B) and increased the SOD activity (Fig. 3C). Download: Download high-res image (756KB) Download: Download full-size image Fig. 3. JWJGC reduces ROS expression in CIA rats. ...
Download: Download full-size image Figure 1. Pedigree Structures of Families W10-3099 and M328, Photographs of Affected Individuals, and Illustration of Homozygosity Mapping (A) The pedigree structure of family W10-3099. The asterisks indicate the individuals used for homozygosity mapping and CNV anal...
We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonical Wnt/β-cateni
Full size image SLC7A11 is highly expressed and positively correlated with SIRT3 expression in GBM tissues To confirm the high positive correlation between SIRT3 and SLC7A11 expression, we also applied tissue microarray staining to compare the expression levels of SLC7A11 between GBM and normal br...
Full size image Table 1 Spectral and biochemical properties of SulfOFF-1 and Thyone in solution Full size table To assess selectivity, we characterized the affinity of Thyone to different anions compared to its precursor mNeonGreen. The mNG-C149Y/W167Y variant was used as an additional referen...