A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem 2002;277:19131-8.Pandey, A., Ibarrola, N., Kratchmarova, I., Fernandez, M.M., Constantinescu, S.N., Ohara, O., Sawasdikosol, ...
Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-... Engagement of the TCR or of chemokine receptors such as CXCR4 induces adhesion and migration of T cells via so-called inside-out signalin...
Cloning and expression of human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolate...
SLAP2 associates in a ligand-dependent manner with KIT through its SH2 domain Full size image SLAP2 associates mainly through pY568 and pY570 in KIT SLAP2 associates with KIT mainly via the pY568 and pY570 residues in KIT: COS-1 cells were transfected with SLAP2-FLAG plasmid. Cells were...
SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This c...
Minvielle-Sebastia L, Winsor B, Bonneaud N et al (1991) Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein. Mol Cell Biol 11:3075–3087PubMedCentralPubMed 16. Dass B, Tardif S, Pa...
On the other hand, if we consider a function ϕ on the domain of the X variables, defined as ϕ(X) = 1 − δ(X), where δ(X) is the Dirac delta function (assuming null value for every X ≠ 0), i.e. ϕ(X) = {1 if X > 0, and 0 otherwise...
Fig. 1 SLAP, SLAP2, and SRC display similar structural features. SLAP family proteins, SLAP and SLAP2, share SRC homology 3 (SH3) and SRC homology 2 (SH2) domains with SRC. However, the kinase domain of SRC is absent in SLAP and SLAP2......
Cloning and expression of human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expressionThe present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated...
Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein ...