内容提示: SCF(Skp1-Cul1-F-box 蛋白)复合物及其在细胞周期中的作用刘卫霞 彭小忠 袁建刚* 强伯勤*(中国医学科学院基础医学研究所, 中国协和医科大学基础医学院 北京 100005)摘要 泛素 - 蛋白酶体降解途径在多种蛋白浓度的调节中发挥重要作用。泛素连接酶家族的一个成员 SCF 复合物(Skp1-Cul1-F-box 蛋白)通过...
SKP1disease progressionmolecular targetThe correct synthesis and degradation of proteins are vital for numerous biological processes in the human body, with protein degradation primarily facilitated by the ubiquitin-proteasome system. The SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase, a member of the ...
Skp1 in lung cancer: Clinical significance and therapeutic efficacy of its small molecule inhibitors Skp1 is an essential adaptor protein of the Skp1-Cul1-F-box protein complex and is able to stabilize the conformation of some ubiquitin E3 ligases. However, the role Skp1 plays during tumorigenes...
该课题组对与 EN884 一起孵育的SKP1-FBXO7-CUL1-RBX1复合物进行了串联质谱(MS/MS)分析,以确定修饰位点(图4),发现了一个被修饰的位点——SKP1上的C160(图5),该位点由于特定的F-Box结构域,表现出独特的构象。因此,该课题组假设EN884可能会利用S...
The Skp1-Cul1-F-box (SCF) and anaphase- promoting complex (APC) ubiquitin ligases target numerous components of the cell cycle machinery for destruction. Throughout the cell cycle, these ligases cooperate to maintain precise levels of key regulatory proteins, and indirectly, each other. Recently,...
Keywords: scf复合物,skp1,cul1,f-box蛋白,g1-s期,中心体 Full-Text Cite this paper Add to My Lib Abstract: 泛素-蛋白酶体降解途径在多种蛋白浓度的调节中发挥重要作用。泛素连接酶家族的一个成员scf复合物(skp1-cul1-f-box蛋白)通过降解多个细胞周期调节蛋白促使细胞进入增殖周期。本文综述了scf复合物...
S期激酶相关蛋白1(S-phase kinase-associated protein 1,SKP1)作为SCF(Skp1-Cul1-F-box)复合体的接头蛋白,分别连接Cullin-1(Cul1)和F-box蛋白.该家族蛋白参与植物生长发育的调控,并响应生物/非生物胁迫逆境.为揭示该家族成员在小麦(Triticum aestivum)这一重要农作物中的基本生物学特性和功能,本研究自小麦中鉴定...
产品介绍:Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. ...
Skp1-Cul1-F-盒蛋白(SCF)复合体在蛋白质的泛素化修饰和降解中发挥重要作用。SCF复合体由Skp1、Cullin1、F-盒蛋白及Rbx1四部分组成,其中Cullin1、多种F-box蛋白、Rbx1已经发现在肺癌等多种癌症中过表达。由于F-box蛋白负责特异底物的识别,其在癌症发生发展中的功能以及特异靶向药物研究也最为广泛。目前研究最为清...
protein 1/2 (尾-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein (SCF) complex (SCF) as an E3 ubiquitin ligase for Wee1A ubiquitination... Watanabe N,Arai H,Nishihara Y,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 656...