by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function....
stem cell nichessenescencewound healingSkin is exposed to the external environment. To maintain its barrier function our skin has to be constantly renewed throughout our lives; this function relay on the skin stem cells. Skin is accepted as the richest resource of stem cells in human body, ...
Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73, 713–724 (1993). Article CAS PubMed Google Scholar Jensen, U.B., Lowell, S. & Watt, F.M. The spatial relationship between stem cells and their...
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cells in other tissues such as pancreatic islets, the cell type that fails to function effectively in type 2 diabetes. As well as making more mature nerves, Dr Philpott's lab is now using similar methods to improve the function of insulin-producing pancreas cells for future therapeutic ...
1Citations Abstract Skin is a complex organ consisting of two very different tissue compartments, the epidermis and the dermis, which comprise cells of diverse origin and function. Establishing and maintaining the functionality of skin requires not only tightly regulated processes of maturation and diff...
The skin epidermis is continually influenced by a myriad of internal and external elements. At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair regeneration with powerful self-renewal ability, as well as keeping dive
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Using human skin cells, University of California, Irvine neurobiologists and their colleagues have created a method to generate one of the principle cell types of the brain called microglia, which play a key role in preserving the function of neural networks and responding to injury and disease....
Transplantation of bone-marrow-derived mesenchymal and epidermal stem cells contribute to wound healing with different regenerative features A new concept for wound therapy is the initiation of the regeneration of epidermal and dermal layers with appendages for skin function recovery. Bone-marro... LH ...