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Also, anti-programmed cell death ligand-1 (aPD-1) has been used for transdermal immunotherapy of melanoma[152]. Concurrent transdermal delivery of aPD-1 and 1-methyl-DL-tryptophan (1-MT) conjugated with HA using MNs, successfully penetrated the mice's skin, induced immunity, delayed melanoma...
Epidermis protein of sacrificed modeling mice were collected and stored at -80 ̊C and subjected to a single freeze–thaw cycle. Mouse IL-17A kits from BOSTER (Wu Han, China) were used. ELISA assay was performed according to the manufacturer’s instructions. Cell apoptosis assays The cell ...
( rosmarinus officinalis ), which along with the related compound carnosic acid, is responsible for about 90% of rosemary's antioxidant activity. in cell culture, it sensitizes melanoma cells to the damaging effects of x-ray radiation, increasing cellular death by 34% compared to radiation alone...
The skin constitutes the primary physical barrier between vertebrates and their external environment. Characterization of skin microorganisms is essential for understanding how a host evolves in association with its microbial symbionts, modeling immune system development, diagnosing illnesses, and exploring the...
it was found that incorrect applications of moisturisers before and after PPE application may increase infection risk28. Previous investigations on PPE have mainly focussed on modelling the pressure that acts on the surface of the skin, with the objective of ensuring an appropriate seal and maintaini...
If my first full year living in NYC and modeling has taught me anything, it is that making rigid plans is a little pointless, so you’ve got to learn to love the spontaneity of it all. That attitude can bring incredible experiences, and I’m excited for more! It’s also helping me ...
pyogenes caused programmed cell death of skin epithelial cells, immunofluorescence staining of caspase-1 was performed 24-h post-epicutaneous infection. We saw a marked decrease of caspase-1 expression in epithelial cells infected with the ΔarcA in only WT mice (Figures 4F and 4G). S. pyogenes...
by Judith Curry Some reflections on my transition from academic climate research to private sector weather forecasting and regional climate change assessments. I've received thousand of emails, tweets, etc. regarding my retirement from Georgia Tech. Two
Depending upon the payload, the compositions of the invention can induce cell death in circulating tumor cells (CTC) in a subject, e.g., by administering the compositions intravenously. Furthermore, depending upon payload, the compositions of the invention can prevent or reduce onset of metastasis...