treatment contexts.#Microneedles (MNs) are used extensively for treating skin diseases due to their capability to provide less-invasive targeted drug delivery.#Intelligent MNs can be fabricated from biocompatible materials with specialized properties, thereby providing improved treatment efficacy.#Currently, ...
DermaFrac™by Genesis Biosystems is an advanced skin rejuvenation technology combining micro-needling with simultaneous infusion. This modular system provides the option to add microdermabrasion and/or LED for an efficient, comprehensive treatment: ...
Therefore, we have developed a unique fabrication process to generate hollow micro- needle arrays from polymerized SU-8, which subsequently undergo UV/ozone treatment to make the surfaces hydrophilic. Based on the hydrophilic nature of the microneedles, dermal interstitial fluid is autonomously extracted...
Therefore, we have developed a unique fabrication process to generate hollow microneedle arrays from polymerized SU-8, which subsequently undergo UV/ozone treatment to make the surfaces hydrophilic. Based on the hydrophilic nature of the microneedles, dermal interstitial fluid is autonomously extracted ...
By combining the structural advantages of polymeric vectors and the versatile properties of poly(β-amino ester)s (PAEs) based systems [12], [13], our research group developed highly branched poly(β-amino ester)s (HPAEs) for the treatment of a representative monogenic skin disease – ...
For each case, we compared the direct delivery of the treatment with the dMNA delivery, which was achieved by shaving off tip-loaded microneedles from the fabricated dMNAs into the cell media. After 24 h, we measured the NF-κβ expression (Fig. 3D, left). The CA-EVs inhibited NF-κ...
treatment of inflammatory skin disease and perhaps most importantly create a new platform for performing systematic screening and evaluation of therapeutic mRNA targets among the many cytokine and cytokine-regulating players involved in psoriasis pathogenesis. Hence, by combining gene-specific targeting with...
(ADSC- EVs) to the skin.97 Their findings validated that microneedles are an effective means of delivering drugs to the skin, thereby improving treatment outcomes.97 More recently, Van Dat Bui et al developed a dissolving microneedle patch (EV@MN) composed of hyaluronic acid and loaded it ...
for the treatment of inflammatory bowel disease.132 Solid lipid nanoparticles (SLN) SLN are novel colloidal delivery systems comprise of biocompatible lipid nucleus and an amphiphilic surfactant in the outer shell with size range of 50 to 1,000 nm (Figure 4, G). These symbolize an unconventional...
treatment of inflammatory skin disease and perhaps most importantly create a new platform for performing systematic screening and evaluation of therapeutic mRNA targets among the many cytokine and cytokine-regulating players involved in psoriasis pathogenesis. Hence, by combining gene-specific targeting with...