The EpiSkin™ skin corrosion test method was formally validated and adopted within the context of OECD TG 431 for identifying corrosive and non-corrosive chemicals. The EU Classification, Labelling and Packaging Regulation (EU CLP) system requires the sub-categorisation of corrosive chemicals into ...
skin corrosionhuman skin testskinThe test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non‐corrosive substances and mixtures when supported by a weight of evidence determination using other existing information...
When combined within tiered testing strategies in either a top-down or a bottom-up approach for predicting the potential skin irritation and corrosion hazard of a test chemical, the currently validated and adopted in vitro methods for skin irritation and corrosion can replace the traditional in ...
Similarly, dermal irritation and corrosion tests using rabbits revealed no mortality, clinical signs of toxicity, and acute irritation or corrosion reaction on the skin. In a skin sensitization test using guinea pigs, there were no significant mortality, clinical signs of toxicity, body weight ...
To assess cell barrier impermeability, 1% Triton-X100 (Sigma-Aladrich, Darmstadt, Germany) was added on top of the epidermal tissue and incubated over 4 h at 37 °C [14], and subsequently cell viability was measured with CCK-8 (Sigma Aldrich, Darmstadt, Germany) [17]. Corrosion and irrit...