We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation.
Figure 2. TEWL findings and factors contributing to epithelial barrier dysfunction in AD against healthy skin. AD, atopic dermatitis; TEWL, transepidermal water loss. Recent studies have revealed that distinct skin endotypes are found in individuals with AD but without FA, AD, and FA and FA with...
Electrical impedance assay Measure the electrical current passing through the skin, assessing changes in skin resistance to evaluate both the integrity of the skin barrier and variations in moisture content. Stimulation epidermal differentiation assay E.g. filaggrin, involucrin, transglutaminase, cytokeratin...
Journal of Molecular Medicine (2024) 102:1457–1470 https://doi.org/10.1007/s00109-024-02491-z ORIGINAL ARTICLE Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose‑exposed dermal fibroblasts and diabetic skins Dong Yeon Kim1 · Young‑Hee...
This can be caused by a lack of protection, which allows more chemicals, pollutants, and irritants to get into the skin, notes Dr. Gmyrek. Skin barrier dysfunction is also inextricably intertwined with having sensitive skin.“Many of my patients who think they have sensitive skin actually just...
Filaggrin mutations can lead to reduced SC natural moisturizing factor (NMF) components, increased pH in the SC, and consequent dysfunction of the skin barrier (6). Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an im...
barrier in AD. Although permeability and antimicrobial dysfunction are well-known features of AD, only recently has the likely reason become clear: these two functions are co-regulated and interdependent [22]. Failure of the permeability barrier favors secondary infection; conversely, pathogen colonizati...
Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction Chiang-Wen Lee Zih-Chan Lin Jia-You Fang ArticleOpen Access17 Jun 2016 Scientific Reports Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma ...
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a complex, heterogeneous pathogenesis including skin barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) is essential for epithelial homeostasis and wound healing, the effect of EGF on AD rema...
Lim Skin barrier dysfunction and filaggrin Arch Pharm Res (Seoul), 44 (1) (2021 Jan 1), pp. 36-48 CrossrefView in ScopusGoogle Scholar 44 H. Jeon, G. Kim, A. Kashif, et al. Pathogenic mechanism of der p 38 as a novel allergen Homologous to RipA and RipB proteins in atopic ...