Only one previous study analyzed small nerve function using an obsolete and not adequate system: the Current Perception Threshold test [5]. This study for the first time provides a comprehensive analysis of the pain symptomatology in a cohort of 25 GD1 patients. In our cohort ERT showed to ...
The ultrastructurc of striated muscle has been re- viewed [118] and will not be discussed here except to point out that arguments relating to the limits of the extracellular volume in muscle [127, 129, 130] should take into account the sarcotubular system [69]. Flistological Approaches ...
In February 1961, Alexander Mauro described a cell 'wedged' between the plasma membrane of the muscle fibre and the surrounding basement membrane. He postulated that it could be a dormant myoblast, poised to repair muscle when needed. In the same month,
maintenance of whole-body glucose homeostasis is the result of a complex regulatory system involving various tissues. Inter-organ crosstalk via a diversity of circulating factors such as hormones and neuropeptides ensures distribution of nutritional components according to the respective need of the specifi...
Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which ...
(4-15% separating gel, Bio-Rad, Hercules, CA, USA) and immunoblotting were carried out with routine protocols. Affinity-purifiedBmal1polyclonal antibody (Sigma-Aldrich, SAB4300614) was visualized with IRDye-conjugated secondary antibody using the Odyssey system (Li-Cor, Lincoln, NE, USA). ...
of adult (12 mo.) and old (24 mo.) mice using three sequential extractions, each one analyzed by liquid chromatography with tandem mass spectrometry. Muscle sections were investigated using fluorescence- and transmission electron microscopy. This study provided the first characterization of the ...