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The wide range of physical abilities possible by humans is achieved by the vast heterogeneity of the structural and functional properties of skeletal muscles. The functional properties of a given skeletal muscle are determined by the relative proportions and collective properties of the individual muscle...
The best-known feature of skeletal muscle is its ability to contract and cause movement. Skeletal muscles act not only to produce movement but also to stop movement, such as resisting gravity to maintain posture. Small, constant adjustments of the skeletal muscles are needed to hold a body upri...
Despite the apparently different topics, they all are focused on the mechanics, properties and function of in vivo human skeletal muscles. Drs. Lieber and Roberts discuss the importance of sarcomere properties, sarcomere non-uniformities and elasticity for the everyday function of muscles. This topic...
The muscular system is composed of three muscle types: smooth muscle, cardiac muscle and skeletal muscle with the latter being the most abundant tissue in the body [185]. The human body contains more than 600 unique skeletal muscles, accounting for 45% of the total body weight [186]. The ...
Furthermore, culturing myospheres can be isolated from the muscles of young and old mice and can be obtained over extended periods of time (3–4 months) [51]. It was evoked that the 3D adhesive cell–cell interactions involved in maintaining the sphere-like myosphere structures are also ...
MicroRNAs are small regulatory noncoding RNAs that repress gene expression at the posttranscriptional level. Previous studies have reported that the expression of miR-23, miR-27, and miR-24, driven from two miR-23–27–24 clusters, is altered by various
Recently, the most utilized methodical approach to isolate stem cells from skeletal muscles is the pre-plate technique (Figure 3) [57]. This method is based on the differing ability of cells to adhere to the cultivation substrate. The first fraction, which adhered to substrate, is composed pre...
In the human genome, at least 4–5% of tandem genes are occasionally transcribed into chimeric proteins, suggesting that chimeric RNAs production is a common event with the potential to generate hundreds of additional proteins20. The presence of chimeric RNAs augments the number of transcriptional ...
but also by multiple vertebral, carpal and tarsal fusions5,6. It has been proposed that pathogenic variants inMYH3inhibit TGF-β signaling, which is essential for the normal muscle function. The dysfunction of small muscles that attach at the distal neural arches of the spine is thought to le...