Agents that increase skeletal muscle cAMP levels have beenshown to modulate skeletal muscle mass. The dopamine 1 receptor and its closely relatedhomolog, the dopamine 5 receptor, are G-protein coupled receptors that are expressed in skeletal muscle and increase cAMP levels when activated.Deborah L....
. The rate of decline in grip strength and skeletal muscle mass of the legs was significantly greater than that of skeletal muscle mass of the trunk (P < 0.01). In women, there was a mild decrease in grip strength. As in men, the rate of decrease in the skeletal muscle mass in...
Skeletal muscle index (SMI), as an effective indicator of nutritional status, plays an important role in the prognosis of malignancy. However, the impact of skeletal muscle changes on tumor prognosis has not been systematically elaborated. We aimed to ex
Remarkably, Wwox ablation in SKM is associated with decreased carbohydrate oxidation, fewer slow-twitch muscle fibers, and reduced mitochondrial mass. Mechanistically, WWOX loss is associated with impaired HIF1α and AMPK activity. 2. Results 2.1. The WWOX gene is frequently altered in MetS Genome-...
Associations of abdominal skeletal muscle mass, fat mass, and mortality among men and women with stage I-III colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2020;29:956–65. Article PubMed Google Scholar You Y, Chen Y, Zhang Q, Yan N, Ning Y, Cao Q. Muscle quality index is ...
Moreover, skeletal muscle mass, myofibre structure and fibre cross-sectional area (CSA) distribution were not affected by PGC-1b ablation in myofibres (Supplementary Fig. 1e–i). As overexpression of PGC-1b has been shown to drive the formation of type IIX fibres in skeletal muscle32, we...
high skeletal muscle mass [38–44]. During intense exercise such as under racing conditions a Thoroughbred may increase its metabolic rate from basal levels by up to 60-fold [45]. Furthermore, the Thoroughbred has a very high skeletal muscle mass comprising over 55% of total body mass [46...
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(D) Bar chart showing quantification of percent contribution by the different skeletal fates to total graft mass for grafts derived from fetal hSSCs, adult hSSCs, skeletal-induced-iPSC, B-HAS, or BMP2 + sVEGFR-treated HAS after morphometric analysis. See also Table S2. Single-Cell Transcripto...
Among them, arginase-II (Arg2) has been reported to promote endothelial cell senescence and vascular smooth muscle cell senescence.45,46,47 Arg2 deficiency plays an important role in lifespan extension in mice.48 Thus, we chose Arg2 for further study. We verified significantly increased mRNA ...