After batch correction and integration of single-cell and single-nucleus data by single-cell variational inference (scVI)22autoencoder (see Supplementary Note1for comparison with Harmony15), we annotated 40 major human skeletal muscle populations, each displaying canonical marker genes (Fig.1c, Extend...
A. et al. Skeletal muscle transcriptomic comparison between long-term trained and untrained men and women. Cell Rep. 31, 107808 (2020). Article CAS PubMed Google Scholar Deshmukh, A. S. et al. Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific ...
4 In comparison to the muscle fibers, the intramuscular vasculature displays a broader constitutive chemokine expression pattern with detectable levels of CXCL1-2-3-8-10-11-12 and CCL2-4.5 In addition, tumor necrosis factor (TNF) -related apoptosis inducing ligand (TRAIL) is expressed in ...
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, such as resistance exercise (RE), might provide insight to the con...
Comparison of Three Antagonists of Hedgehog Pathway to Promote Skeletal Muscle Regeneration after High Dose Irradiationdoi:10.1667/RADE-23-00140.1HEDGEHOG signaling proteinsSKELETAL muscleBASAL cell carcinomaSATELLITE cellsRADIATION exposureMUSCLE regeneration...
addition of endothelial cells to neuromuscular cocultures downregulatedLRP4while promoting expression of muscle-specific kinase (MUSK) gene. Ordinary one-way ANOVA analysis with Tukey’s multiple comparison test was performed withn = 3 replicates per group, andp < 0.05 was considered for st...
Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography J Appl Physiol, 85 (1998), pp. 115-122 CrossrefView in ScopusGoogle Scholar 2 Engstrom CM, Loeb GE, Reid JG, Forrest WJ, Avruch L Morphometry of the human thigh muscles.Acomparison betwee...
Significant GO terms of DE genes (DEGs) of each comparison library in TC and YK. Full size image Pathway enrichment analysis between TC and YK To identify the biological pathways that were involved in muscle development, we mapped the DE genes (4,331 in TC and 2,259 in YK pigs) to the...
Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway that is regulated by skeletal muscle interferon regulatory factor (IRF) 4, which ma
The spiny mouse,Acomys cahirinus, is an adult mammal capable of remarkable feats of scar-free tissue regeneration after damage to several organs including the skin and the heart. Here we investigate the regenerative properties of the skeletal muscle ofA.cahirinustibialis anterior in comparison to the...