Nucleus sizePloidyIn order to better understand which are the factors involved in the control of nuclear size, and more precisely, to clarify why nuclear hypertrophy doesnt always follow genome increase, biological techniques combined with a strict mathematical approach have been applied to study the ...
Cell NucleusHumansTritiumDNAThymidinePhotometryCulture TechniquesAutoradiographyRelative nuclear DNA content and nuclear area were determined in fast growing, karyotypically normal, fibroblastic cell cultures derived from five human females. In two cultures H3 thymidine autoradiographic and photometric ...
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capability of a nucleus to sustain a given cytoplasmic volume disrupts cellular processes in organisms from yeast to mammalian cells2,13,14. While the number of myonuclei positively correlates with cell size in mice and humans, the threshold of myonuclei needed to achieve target cell size and ...
The size of the membrane-bound nucleus scales with cell size in a wide range of cell types but the mechanisms determining overall nuclear size remain largely unknown. Here we investigate the role of fission yeast inner nuclear membrane proteins in determining nuclear size, and propose that the La...
(David Kopf Instruments, Tujunga, CA). The right brain caudate nucleus (orthotopic RG-2 glioma)[28] and left temporalis muscle (ectopic RG-2 glioma) locations were stereotactically inoculated with 105RG-2 glioma cells in 5 μL of sterile PBS. In each location, the cells were injected ...
To specifically assess the nucleus size and its relationship to cell size for human bulbar conjunctival cells. Impression cytology samples were taken from the nasal side of the intra-palpebral zone of the bulbar conjunctival surface from 20 young adult white European males, half of whom were succes...
Cell sizes were measured in counting boxes and then divided into individual cortical layers according to cytoarchitectonic criteria established previously.22 D, Schematic drawing of diameter circle (D-circle), the parameter used to estimate soma size. Figure 2. View LargeDownload A, Photographs of ...
In eukaryotic cells, a distinctive feature of intracellular organization is the nucleus, a membrane-enclosed organelle that harbors most of the cell’s genetic material. The nuclear envelope hereby spatially confines the genetic material and physically separates transcription and translation. While the ...