Our bioinformatics study estimates the size of 'druggable' human genome to be around 20% of human proteome, i.e. the number of the possible protein targets for small-molecule drug design in medicinal chemistry. We do not take into account any toxicity prediction, the three-dimensional ...
但人类并不是基因组大小（genome size）最大的生物。基因组大小并不直接与生物的复杂性成正比，这个现象...
Evolutionary analyses of the human genome The completion of the human genome will greatly accelerate the development of a new branch of science-evolutionary genomics. We can now directly address im... WH Li,Z Gu,H Wang,... - 《Nature》...
These results suggest that tooth-size increase in 47,XXY males is due to a direct genetic effect and support the concept of the presence of a specific growth gene (or genes) in the human X and Y chromosomes. The effect of this gene (or genes) seems to be the promotion of tooth ...
The effect of selection on variation at one location in the genome and on evolution at other, genetically linked sites. Selective sweep The process by which a new favourable mutation becomes fixed so quickly that variants that are closely linked to it, and that are present in the chromosome on...
Strong purifying selection is considered a major evolutionary force behind small microbial genomes in the resource-poor photic ocean. However, very little is currently known about how the size of prokaryotic genomes evolves in the global ocean and whethe
Variation in genome size of 24 populations belonging to 11 NW Patagonian species of Berberis was analysed as a function of the environment and geographical... MCJ Bottini,EJ Greizerstein,MB Aulicino,... - 《Annals of Botany》 被引量: 131发表: 2000年 Repetitive DNA in the automictic fungus...
Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formati... Y Jennifer,RM White,DC Wedge,... - 《Genome Biology》 被引量: 0发表: 2019年 Effect of simulated water stress on the physiology ...
In man, for example, the DNA content of diploid cells has been estimated to be 6 pg (Vendrely and Vendrely, 1957), and a comparison with other species has shown that the DNA content of human diploid cells is similar to that of placental mammals (Atkin et al., 1965)....
next highest number, 125. Gorillas have 99, marmosets 30 and mice just one. "The one over-riding theme that we saw repeatedly was that the more copies of DUF1220 in the genome, the bigger the brain. And this held true whether we looked at different species or within the human ...