molecules Article Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication Kohei Umehara 1,†, Miho Hoshikawa 1,†, Naoya Tochio 2,‡ and Shin-ichi Tate 1,2,* ID 1 Department of ...