Hendler has found that material derived from the endoplasmic reticulum, which in other tissues is recovered from homogenates by centrifuging at 105,000gfor 60 min, is in this tissue to be found, together with nuclei, mitochondria and unbroken cells, in the fraction sedimenting at 600gfor ...
The lipid/protein interface as a target site for general anesthetics:a multiple-site kinetic analysis of synaptosomal Ca2+-ATPase[J].{H}Biochemica and Biophysical Acta,1998,(01):174-180.Pflugmacher D, Sandermann HJ: The lipid/protein interface as a target site for general anesthetics: A ...
Dietary fat and protein appear to exert their effects on hepatic lipid synthesis by different mechanisms. The depression in hepatic fatty acid synthesis brought about by fasting or fat-feeding is accompanied, and probably preceded, by an increased plasma free fatty acid level. Under these conditions...
Regardless of the functionalization strategy, careful consideration must be paid to the reaction conditions for protein modification. Due to the fragility and massive size of most full-length proteins, the chemistries employed must occur under mild, aqueous conditions and proceed relatively rapidly on su...
The goal of this study was to define the membrane topology and the amino acid sequence motifs required for PlsY activity. We used the PlsY of Streptococcus pneumoniae as the prototypical protein to study this widely expressed and highly conserved family of membrane acyltransferases. EXPERIMENTAL ...
protein interaction offers the essential basis for carbohydrate drug development2,3. Previous studies have shown that carbohydrates act as ligands of sialidase to mediate virion release4,5. This finding has been converted into the discovery of the well-known medications zanamivir and oseltamivir6. ...
Dietary fat and protein appear to exert their effects on hepatic lipid synthesis by different mechanisms. The depression in hepatic fatty acid synthesis brought about by fasting or fat-feeding is accompanied, and probably preceded, by an increased plasma free fatty acid level. Under these conditions...
Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. In plants, two pathways are utilized for the synthesis of isopentenyl diphosphate, the universal precursor for isoprenoid biosynthesis. The key enzyme of t... A Hemmerlin...
in fibroblasts ofmucolipidosis type IImice and Niemann-Pick type C patients characterized by aberrant cholesterol accumulation, the proteolytic cleavage of the α/β-subunit precursor was not impaired. We conclude that S1P substrate-dependent regulatory mechanisms forlipid synthesisand biogenesis of lysosom...
Nucleic acids encoding genes with SepRS and tRNASep activity for site specific incorporation of phosphoserine into a protein or polypeptide and methods of use thereof are described.