SIRT6 concentrations were significantly higher in non-cachectic cancer patients (3.41 ± 0.30 ng/mL) compared to cachectic cancer patients (3.20 ± 0.23 ng/mL, p < 0.01), suggesting the negative ...
CAS号: 3023471-40-8 英文名: SIRT6-IN-3 英文别名: SIRT6-IN-3 中文名: 化合物 SIRT6-IN-3 中文别名: 化合物 SIRT6-IN-3 CBNumber: CB814291115 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 2 化合物 SIRT6-IN-3化学性质 ...
綜合上述實驗結果得知:一,SIRT6無法作為PAX3的輔因子,但能維持PAX3在細胞中的穩定性.二,PAX3的第271個胺基酸突變和SIRT6有較強的交互作用,並改變SIRT6在細胞中的分布,可能與致病機制有所關連.三,SIRT6可作為p53的輔因子抑制下游基因p21的轉錄活性.四,SIRT6在核仁中具有功能.In eukaryotes, chromatin structure...
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来自于 J Biol Rhythms. 2010 Oct;文章:JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets 。 具体代码下载地址在:https://s3-us-west-2.amazonaws.com/oww-files-public/8/88/JTKversion3.zip 曾老师将其同步更新在:https://github.com/jmzeng131...
functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their ...
[3]CHEN C, ZHOU M, GE Y, et al. SIRT1 and aging relatedsignaling pathways[J]. Mechanisms of ageing and development, 2020, 187(111215. [4]NGUYEN N N, RANA A, GOLDMAN C, et al. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila ...
Bronchial epithelial SIRT1 deficiency exacerbates cigarette smoke induced emphysema in mice through the FOXO3/PINK1 pathway. Exp Lung Res, 2022: 1-16. 9. Brenmoehl J, Hoeflich A. Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion, 2013, 13(6): 755-761. ...
SirT3 (D22A3) Rabbit mAb #5490 100 µl Product Information Product Usage Information ApplicationDilution Western Blotting 1:1000 Immunoprecipitation 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot...
10月29日,上海交通大学医学院细胞分化与凋亡教育部重点实验室张健与陈国强两个课题组合作,在Nature Chemical Biology发表了题为Identification of a cellularly active SIRT6 allosteric activator的药物设计研究论文,报道首个(First-in-cl...