PGC-1 α/ERRα-Sirt3 pathway regulates DAergic neuronal death by directly deacetylating SOD2 and ATP synthase β [J]. Antioxid Redox Signal, 2016, 24: 312-328.Zhang X,Ren X,Zhang Q,et al. PGC-1a/ERRa-Sirt3 PathwayRegulates DAergic Neuronal Death by Directly Deacetylating SOD2and ATP...
我们目前的发现表明,AMPK激活在DHM介导的SIRT3表达调节中起关键作用。 在DHM处理后,萤光素酶的SIRT3启动子依赖性表达显着增加,并通过PGC1αsiRNA或ERRαsiRNA转染而减弱(图7I)。这些结果表明DHM通过PGC1α依赖性ERRα介导的信号通路促进SIRT3基因转录。 实际上,在用DHM刺激后,在HepG2细胞上进行的ChIP测定显示出P...
PGC-1α通过上调SIRT3表达发挥心肌保护作用 万方数据
Naringenin regulates gut microbiota and SIRT1/PGC-1a signaling pathway in rats with letrozole-induced polycystic ovary syndrome. Biomed. Pharmacother. 153, 113286 (2022) Article CAS PubMed Google Scholar B. Zhang et al. SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in...
SIRT3 was induced by PGC-1β together with ERRα during RANKL-induced osteoclast differentia- tion, and it may function as a negative mediator for osteoclastogenesis through stabilization of AMPK protein. Thus, our data suggest that SIRT3 plays an important role as a molecular brake on ...
PGC1a Monoclonal antibody 66369-1-Ig SIRT5 Polyclonal antibody 15122-1-AP ACSS1 Polyclonal antibody 17138-1-AP SIRT1 Polyclonal antibody 13161-1-AP SIRT2 Polyclonal antibody 19655-1-AP P53 Polyclonal antibody 10442-1-AP PGC1a Monoclonal antibody 66369-1-Ig SIRT5 Polyclonal antibody 15122-1-AP...
但是,当用AMPK特异性抑制剂化合物C(CC)预处理HepG2细胞或用AMPK siRNA转染HepG2细胞时,DHM对PA诱导的AMPK磷酸化减少以及PGC1α和SIRT3表达减少的抑制作用被消除(图7G,H)。我们目前的发现表明,AMPK激活在DHM介导的SIRT3表达调节中起...
说明SIRT3可能通过活化FoxO3a/PGC-1α抗氧化通路减轻氧化应激引起的肺损伤,发挥保护作用。 琥珀酰脱氢酶(succinate dehydrogenase,SDH)是存在于TCA循环(三羧酸循环)和电子传递链两条通路中的线粒体内膜结合酶。有报道称,抑制SDH相关的琥珀酸/HIF-1a信号通路,通过对抗脂肪酸氧化,降低琥珀酸积累,可以显著减少ROS的产生...
高糖对心肌细胞损害调节新机制:烟酰胺核糖通过Sirt3-p53/PGC-1α改善线粒体自噬及线粒体合成 认领 被引量:3 Nicotinamide riboside alleviates high glucose injury in adult mouse cardiomyocytes via the Sirt3-PGC-1a/p53 pathway through mitochondrial synthesis and mitochondrial autophagy ...
Furthermore, it has been shown that the activation of SIRT3 causes increased mRNA levels of PGC-1α, leading to reduced oxidative stress and improved mitochondrial function in a mouse model of pressure overload hypertrophy [83]. On the other hand, however, research also showed that PGC-1a ...