Additionally, it delves into the unique features of SIRT7, discussing their potential and specific implications in tumor initiation and progression, underscoring the promising avenue of targeting SIRT7 for the development of innovative anti-cancer therapies....
图表改编自Globocan 2020的《全球癌症观察》(Global Cancer Observatory) 我国《原发性肝癌诊疗指南(2022年版)》[2]推荐的肝癌治疗手段主要为外科治疗、消融治疗、经动脉化疗栓塞(TACE)、放射治疗(如钇90[90Y]内放射治疗)、系统抗肿瘤治疗等。 在局...
《Biliary cancer: ESMO ClinicalPractice Guidelines for diagnosis, treatment and follow-up》。发表于 2016 年《Annals of Oncology》 ;27(Suppl 5): v28-v37.
2. Valle JW、Borbath I、Khan SA、Huguet F,Gruenberger T 和 Arnold D,代表欧洲肿瘤内科学会指南委员会。《Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up》。发表于 2016 年《Annals of Oncology》 ; 27(Suppl 5): v28-v37. ...
14. Zhang W, et alLenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm, phase II trial. J Immunother Cancer. 2023 Sep;11(9):e007366. 15. Zhu XD, et al. Hepatectomy After Conversion Therapy Using...
are mainly dependent on ellagic acid-mediated SIRT6 activation. Our results provide preclinical rationale for using ellagic acid as a feasible and promising agent to ameliorate cisplatin-induced acute kidney injury, and support ellagic acid as a potential adjunctive therapy for future cancer treatment....
The cell-cycle checkpoint kinase WEE1 is emerging as a therapeutic target for cancer treatment. However, how its catalytic activity is regulated remains poorly understood, and reliable biomarkers for predicting response to WEE1 inhibitor remain to be identified. Here we identify an evolutionarily conse...
histone.SIRT1is associated with many diseases,such as metabolism,inflammation and cancer,and is expected to become a new target for cancer treatment.In this paper,the development of SIRT1 inhibitors in recent years and their problems are summarized,which will provide some references for the future...
止肿瘤的发展和增加寿命仍然是未知的。带有烟酰 胺(NAD)依赖性Ⅲ型组蛋白脱乙酰基酶活性的 SIRT1(酵母菌Sir2同源基因),可能是与肿瘤和衰老 调节相联系的关键基因。SIRT1在生长调节、应激应 答、肿瘤形成和内分泌信号上有着广泛的生物学功 能,同时能延长寿命。这里,我们关注的是目前关于 ...
Treatment of hepato-cellular carci 25、noma J.Crit Rev Oncol Hematol ,2006,60(2):89-98.3Yeo W, Mok TS, Zee B, et al. A randomized phase III study of doxorubicin versus cispl atin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unrese- ctable hepatocellular ...