DNA结合蛋白DNA复制单链DNA蛋白A真核细胞人类基因组真核生物哺乳动物Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication,recombinational repair,and maintenance of genome stability.In human,the major SSB,replication protein A (RPA),is a stable heterotrimer composed of ...
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Single-Stranded DNA-Binding Proteins (SSBs) A.L. Eggler, in Encyclopedia of Genetics, 2001 Replication Owing to the intrinsic nature of replication, the process involves unwinding dsDNA to generate ssDNA. The capability of SSBs to bind ssDNA and interact functionally and physically with other p...
Single-stranded DNA-binding proteins (SSBs) play essential roles in DNA replication,recombinational repair,and maintenance of genome stability.In human,the major SSB,replication protein A (RPA),is a stable heterotrimer composed of subunits of RPA1,RPA2,and RPA3,each df which is conserved not ...
The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA replica
Single-Stranded DNA-Binding Proteins Thesingle-stranded DNAof the lagging strand created by the action of the helicase is covered by tightly binding single-stranded DNA-binding proteins. InE. coli, this protein is a tetramer known as single-stranded-binding (SSB) protein, which the ssDNA winds ...
Single-strand DNA (ssDNA)-binding proteins (SSBs) are ubiquitous and essential for a wide variety of DNA metabolic processes, including DNA replication, recombination, DNA damage detection and repair. SSBs have multiple roles in binding and sequestering ssDNA, detecting DNA damage, stimulating nuclease...
DnaT is one of the replication restart primosomal proteins required for reinitiating chromosomal DNA replication in bacteria. In this study, we identified and characterized the single-stranded DNA (ssDNA)-binding properties of DnaT using electrophoretic mobility shift analysis (EMSA), bioinformatic tools...
Single-stranded DNA-binding proteins (SSBs) play vital roles in all aspects of DNA metabolism in all three domains of life and are characterized by the presence of one or more OB fold ssDNA-binding domains. Here, using the genetically tractable euryarchaeon Haloferax volcanii as a model, we ...
The single-stranded DNA (ssDNA)-binding protein (SSB) of the phage, which is critical for DNA replication, activates several defense systems, including the helicase/nuclease Hna proteins from Sinorhizobium meliloti and Escherichia coli, Retron-Eco8 from E. coli, and nuclease-helicase immunity (Nhi...