Both proteins inhibit the dATPase activity of RecA protein in spite of a large proportion of RecA protein still complexed to single-stranded DNA. Analysis of the multiple RecA protein activities and how they respond to the presence of SSB suggests that they fall into two distinct classes. Those...
The single-stranded DNA (ssDNA)-binding protein (SSB) of bacteriophage φ29 is one of the virus-encoded proteins required for viral DNA replication. We have found that φ29 SSB has helix-destabilizing activity since it removes secondary structure of the ssDNA in φ29 replicative intermediates, ...
3National Center for Protein Science Shang- hai, 320 Yueyang Road, Shanghai 200031, China Human single-strand (ss) DNA binding proteins 1 and 2 (hSSB1 and 2) are components of the hSSB1/2-INTS3- C9orf80 heterotrimeric protein complex shown to participate in DNA damage response and maint...
Single-strand bindingproteins bind to the two strands to prevent them from reannealing. ... Synthesizing ssDNA during DNA replication is important because it allows duplication of genetic material and thus the reproduction of cells. Another role of ssDNA is to aid with DNA repair. ...
F. Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. J. Biol. Chem. 281, 13939–13948 (2006). Article CAS PubMed Google Scholar Rass, U., Ahel, I. & West, S. C. Defective DNA repair...
The DNA in dormant spores of Bacillus species is saturated with a group of nonspecific DNA-binding proteins, termed alpha/beta-type small, acid-soluble spo... H Fairhead,B Setlow,P Setlow - 《Journal of Bacteriology》 被引量: 236发表: 1993年 Status of nuclear division in arbuscular mycorr...
The process of displacing the single-stranded DNA-binding protein from single-stranded DNA by RecO and RecR proteins The regions of single-stranded (ss) DNA that result from DNA damage are immediately coated by the ssDNA-binding protein (SSB). RecF pathway proteins facili... I Jin,H Masayos...
Unexpectedly, addition of PARP inhibitor 2h after DMS treatment still increased SSB levels indicating ongoing repair even at this late time point. 展开 关键词: Animals Humans Cell Line DNA Glycosylases Poly(ADP-ribose) Polymerases DNA-Binding Proteins Alkylating Agents Kinetics Gene Knockdown Techniques...
Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins Structural Maintenance of Chromosomes (SMC) proteins are vital for a wide range of processes including chromosome structure and dynamics, gene regulation a... JJ Griese,W Gre...
These proteins are required for SOS mutagenesis, although their mechanism of action is unknown. By using the yeast two-hybrid system we have discovered that MucB interacts with SSB, the single strand DNA binding protein (SSB) of E. coli. To examine the interaction at the protein level, the...