expression levels from low to high.dRepresentative images of Hematoxylin-Eosin staining (left) for TLSs and spatial feature plots of TLS-associated cell types (right) from the Stereo-seq (top;n = 3) and th
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis Article Open access 12 June 2023 Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis ...
2.4. Spatial distribution of OLGs In order to reveal the spatial distribution, the spatial transcriptomics were performed using brainstem stroke mouse model (Fig. 3A). The ST spots were subjected to unsupervised clustering on the basis of the gene expression of each spot (Fig. 5B). The cluster...
Spatial transcriptome and single-cell reveal the role of nucleotide metabolism in colorectal cancer progression and tumor microenvironment Junzhi Liu, Huimin Li, Lantian Wang, Shurui Wang & Qiang Tang Journal of Translational Medicine volume 22, Article number: 702 (2024) Cite this article 5307 ...
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data Article Open access 10 April 2024 Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes Article...
Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidneyHongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Liang...
422 cells from the murine telogen epidermis to systematically dissect the cellular heterogeneity of epidermal cells during tissuehomeostasis. We provide a high-resolution transcriptome map that is available online, present potential novel transcriptional regulators along the differentiation and spatial axes, ...
We utilized scRNA-seq, a well-established technology, to uncover the gene expression characteristics of IL34+ CAFs within HCC. We analyzed the related mechanisms through in vitro and in vivo assays. To begin, we acquired scRNA-seq datasets about HCC, whi
A pan-cancer spatial single-cell transcriptome atlas.aSchematic depicting the study design. The cancer types included in this pan-cancer study were displayed in the first image on the left, created by Figdraw.bThe number of samples in the pan-cancer analysis of scRNA-seq and ST.cPie chart...
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure Proc Natl Acad Sci U S A 11.205 Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development ...