Inflammatory breast cancer (IBC) has an incidence of approximately 2.5 cases per 100 000 women1 and is an especially aggressive form of locally advanced breast cancer. Inflammatory breast cancer is characterized by rapid tumor progression, early metastasis, and poor survival. Multimodal therapy (surger...
Sixty-two men (62%) and 41 women (87%) reported overall scores that fell below one standard deviation of the population mean. There was no significant difference in sexual dysfunction for both male and female patients between low anterior resection, coloanal anastomosis, or abdominoperineal ...
The key exclusion criteria were: bilateral breast cancer, inflammatory breast cancer, or occult breast cancer; other malignancies within five years; serious comorbidities (i.e., uncontrolled hypertension, diabetes mellitus, or active infection); pregnancy, or lactating women. The trial protocol is avai...
Department of Orthopaedics, Brigham and Women’s Hospital, 75 Francis St, Boston, MA, 02115, USA Antonia F. Chen University Orthopedics Center, 3000 Fairway Dr, Altoona, PA, 16602, USA Fred Khalouf University Orthopedics Center, 476 Rolling Ridge Drive, State College, PA, 16801, USA Keith ...
The role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N = 20...
(b) 2.33±0.5 men; 1.60 women; N=998 total Reference: M. Holenberg and Ira B. Tager. Oxygen Uptake Efficiency Slope: An Index of Exercise Performance and Cardiopulmonary Reserve Requiring Only Submaximal Exercise. J. Am Coll Cardiology; 2000; 36:194-201. ...
Identification of serous tubal intraepithelial carcinomas (STIC) in the fallopian tubes of women who are carriers of germ line pathogenic variants in tubo-ovarian cancer predisposition genes (i.e., BRCA1 and BRCA2) has led to the hypothesis that many high-grade serous carcinomas (HGSC) arise ...
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the exis