Michels joined the family company after his military service (I could be wrong, but I’m guessing he didn’t have to interview or work his way too far up the ladder). Tim Michels’ father ran the business until his death, at which time his mother became CEO and Chair of the Board. ...
to scRNAseq count data2,13,14, most single cell workflows begin with a log(x + 1) transformation of the counts matrix, and then use PCA to decompose the resulting “logcounts” data3. The use of logcounts has poor theoretical justification, and in some cases may obscure meaningful v...
the iron-sulfur coordinating cluster (FeS) and the ARCH domain. The C-terminal part includes the nuclear localization signal (NLS), two harmonin N-like domains (HNL1 and HNL2), the PCNA interacting protein motif (PIP), and a C4C4 ring-finger domain...
This scFv works as a “neutralizing agent”, meaning that a complex between prolamin and the scFv is formed in the gut and no systemic interactions are expected, as the formed complex does not cross the epithelial barrier and is finally excreted. Thus, the scFv can be applied as a medical...
Due to the random nature of the N-nucleotide insertions and the not exactly predefined 5’-start and 3’-end of the D-element used during the VDJ recombination step, there will always remain some uncertainty about the exact origin of the respective VDJ gene sequence. Based on the nucleotide...