Centre for Medical Neuroscience, Radboud University Medical Centre Nijmegen, Netherlands; Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK; SBGneuro Ltd, Littlemore, Oxford, UK ...
(ab203443, diluted 1:20; Abcam, Cambridge, UK), and a FITC-labeled CD45 antibody (304006, diluted 1:20; BioLegend). EpCAM+and/or CK+and CD45−cells were defined as CTCs (Fig.1b). Single CTCs from each patient were transferred under direct microscopic visualization to individual PCR...
4g). When the mutation profiles were further analyzed for COSMIC signature 3 that implies homologous recombination deficiency (HRD) status of a patient, which is a frequent driver of tumorigenesis37 and a predictive biomarker38, correlation between weights of signature 3 among all signatures estimated...
Preoperative nutritional and immune status is associated with postoperative complications and the long-term prognosis of patients with malignant tumors [11]. In recent years, some studies have reported that new indicators based on inflammation and nutritional variables have been developed to predict the ...
1b) and that gene mutation and copy number status in the simulated dataset was the same of TCGA (Additional file 1: Figure S1A). As a result, the frequency of damaging alterations in known oncogenes and tumour suppressors was comparable between the two datasets, with TP53, PIK3CA and ...
For the improvement of cognitive function in patients with COPD combined with MCI, We analysed data on the status of changes in oxyhaemoglobin in the prefrontal cortex of the brain during the task (walking) as detected by fNIRS. The fNIRS analysis only considered the single-task condition, as...
Next, having established CNA clone identity of transcriptomes, we were interested in exploring the transcriptional change between distinct clones or distinct treatment status at the same time point (passage). Therefore, we investigated differential transcription among same-passage clones that had the highe...
Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role of vascular endothelial dysfunction in UM rem
Prognostic value evaluation of the CRG model. (a) Distributions of the risk score (RS), survival status distributions, and expression heatmap in the TCGA training cohort. (b) OS value stratified by the RS in the TCGA training cohort. (c) Time-dependent ROC curve of the prognostic performanc...
Each column represents cells in different status. Red and yellow represents high expression level while blue represents low levels Full size image As in relapse, the progenitor cells of P20-post still dominate the bone marrow (Fig. 5c, d and Supplementary Table 9). In the circos plot, the ...