Here, we demonstrate the feasibility of a pre-treatment, single-pass stereotactic needle biopsy to support CLIA-certified genetic screening and tumor PD analysis in a Phase 0/2 clinical trial. METHODS. In support of an ongoing Phase 0/2 'trigger' trial testing CDK4/6 plus ERK1/2 inhibition...
A risk-adjusted antibiotic prophylaxis protocol was developed and applied before each transrectal prostate biopsy. To determine infection risk factors, patients self-reported on a questionnaire. [; Version From the BILE Channels With the Website TRIAD In the event of Hardware CHOLESTASIS (Assessment)....
The sample with a chondroid expression profile was the only biopsy with metaplastic histology, and the clinical pathology independently described chondroid differentiation. Metaplastic BC is a rare and heterogenous subtype associated with poor prognosis overall18 and poor response to cytotoxic chemotherapy19...
Of note, our cohort included one patient, SMM-12, whose biopsy included two distinct subclones. Both subclones harbored a t(11;14) translocation and clonally expressed IgG kappa, suggesting that they descended from the same parental clone, but only one acquired a CD20+ phenotype (Supplementary...
Continuous monitoring of circulating cells can revolutionize various medical fields by enabling real-time measurement of clinically important cells’ population. Although methods such as blood drawing-based technology and in vivo flow cytometry (IVFC) ha
higher engraftment rates are associated with more clinically aggressive tumors such as metastatic or treatment-refractory cases [43], surgically removed metastases or biopsy metastasis samples might extend the application of PDXs to advanced RCCs in terms of technical feasibility and unmet clinical needs....
In this project, about half of screen-negative women has biopsy data, with enough unexpected positive histology results to influence the calculated test performance. Further investigation of the unexpected high number of CIN2 + histology is underway in the form of histology review, ...
A taste test and tongue tissue biopsy will be performed. Eating behaviour and foot preference will be assessed by the Three-Factor Eating Questionnaire (TFEQ-R18) and Slovenian Food Preference Questionnaire, respectively. To assess food intake, a 3-day diet diary will be completed. After visit...
For calcium imaging, there was no minimum activity rate but cells had to be detected in the experiment and pass quality control to be considered for light responsivity. For electrode array, peristimulus activity traces of light responsive cells were clustered by the Infomap method. First, K-...
We show that this approach can be used to interrogate drug-relevant pathways in scant clinical samples. Using the PI3K/PTEN/CDK4/6 pathways in breast cancer as an example, we demonstrate how analysis can be performed in tandem with trial enrollment and can evaluate downstream signaling following...