The Trp64Arg mutation of the β3-adrenergic receptor (β3AR) gene and A to G polymorphism of the uncoupling protein 1 (UCP1) gene are reported to be associ... Tetsuo,Hayakawa,and,... - 《Metabolism-clinical & Experimental》 被引量: 94发表: 1999年 Phenotypic characterization of the β...
Single-nucleotide polymorphismNFKB1 geneCellular senescenceSenescence-associated secretory phenotypeGraft-versus-host disease (GVHD) represents a significant cause of mortality after allogeneic hematopoietic stem cell transplantation (HSCT). NF-kB system is a master regulator of innate immunity responses. It...
To characterize the genetic landscape ofTP53-sAML, we analyzed 33TP53-sAML patients (Supplementary Table1) through bulk-level targeted next-generation sequencing and single nucleotide polymorphism (SNP) array (Extended Data Fig.1). We detected MPN-driver mutations (JAK2andCALR) in 28 patients (85%...
A mosaic such as 45,X[50]/46,X,i(X)(p11.3)[50] would appear similar to 46,X,del(X)(p11.3) in the array data but could be distinguished from the deletion by combined analysis of BAFs and LRRs. SNP, single-nucleotide polymorphism; TS, Turner syndrome. Genetics in medicine | ...
single-nucleotide polymorphism SNS: single-nucleus sequencing WGA: whole genome amplification.References Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, Riggs M, Eberling Y, Troge J, Grubor V, Levy D, Lundin P, Månér S, Zetterberg A, Hicks J, Wigler M: Inferring tum...
Single nucleotide polymorphism (SNP), a common form of genetic variation, is caused by the transition, transversion, insertion, or deletion of individual bases. Expression quantitative trait loci (eQTL) analysis can profile genetic variations (especially SNP) that affect gene expression, offering enhan...
single nucleotide polymorphism 1. Aims and scope of this review Genomic imprinting is an epigenetic mechanism controlling parental-specific gene expression. An imprinted gene is expressed from either the maternal or the paternal allele only. Much of the interest in imprinted genes originates from the...
Specifically, we trained models to predict gene expression from single nucleotide polymorphism genotypes51 using whole-brain bulk RNA-seq from 339 naive HS rats, and estimated the fraction of variance in expression that was explained by cis-genetic variation (r2). We used the trained models to ...
Single-nucleotide polymorphism calls (SNP calls). Following sequencing read assembly, this is the identification of single nucleotides that are different from the nucleotide at the same position in a specific reference genome. This process requires high-quality sequencing and adequate sequencing depth for...
Of these, 435 chickens were genotyped using a 600K single nucleotide polymorphism chip for association analysis. The results indicate that the most significant regions for 9 traits explained 2.38% to 5.09% of the phenotypic variation, from which the region of 194.53 to 194.63Mb on chromosome 1 ...