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normal or diseased tissues, it also provides a cornerstone for studying cell differentiation and development patterns, disease heterogeneity, drug resistance mechanisms, and treatment strategies. Herein, we review traditional single-cell sequencing technologies and outline the latest advancements in single-cel...
A fast and cost-effective strategy is to accurately predict which of the currently existing treatment options is likely to work best for one particular patient (Bzdok and Meyer-Lindenberg 2018; Perna and Nemeroff 2017; Stephan et al. 2017b). Increasing individualization of therapeutic intervention ...
Pankey and Hayes (2003) 1 Single case 22 F -Mild intellectual disability Schizophrenia Supported Living 4 -Reductions in levels of distress from hallucinations-Believability of thoughts reduced-Frequency of hallucinations remained stable None Szabo et al. (2019) 3 Non-concurrent multiple baseline M =...
Generalised epileptic seizures induced in electroconvulsive therapy (ECT) alleviates a wide range of serious conditions, such as severe depression and mania, acute psychosis, catatonia, postpartum psychosis, schizophrenia, status epilepticus and Parkinson’s disease, but its mechanism(s) of action remains...
cell type resolution. The observation of the neuronal glucocorticoid signaling pathway involvement means that neuron-specific glucocorticoid-based treatments could be developed compared with the current glucocorticoid treatments that affect mostcell types, making them not specific and prone to side effects."...
We then compared the outgoing and incoming interaction strength of each pair of cell types to identify significant changes in sending or receiving signals between groups, and used the interaction strength to qualify the drug treatment effect. We then visualized the most significant ligand-receptor ...
CAMHS psychiatrists made the clinical decision to initiate fluoxetine treatment and determined that it was safe for the patient to wait 2–7 days before initiating treatment in order to be able to participate in the study. Exclusion criteria included: history of bipolar disorder or schizophrenia; ...
Thus, taking advantage of scRNA-seq for mapping susceptibility genes to cell types, new insights have been made into the cell types involved, for example, in schizophrenia32,33, neuroticism34, intelligence35,36, and Alzheimer’s disease37, but such analyses have not been attempted for chronic ...
21 Furthermore, the expression of translation factors and ribosomal proteins, such as eIF2B, eIF3, eIF4, eEF1, and eEF2, has been reported aberrantly high in schizophrenia-patients-derived induced pluripotent stem cells.22 Dysfunction in protein synthesis, such as eIF2α signaling pathway, was ...