本发明涉及具有胰岛素活性的单链胰岛素,其包含由5-11个氨基酸的连接肽连接的B和A链或修饰的B和A链. The present invention relates to single-chain insulin having insulin activity, comprising the B and A-chain or modified B and A-chain by a connecting peptide of 5-11 amino acids connected. 该单...
On day 0 of reprogramming, cell culture media was changed to hepato-medium (DMEM:F-12, supplemented with 10% FBS, 1 μg ml−1 insulin (Sigma-Aldrich), 100 nM dexamethasone (Sigma-Aldrich), 10 mM nicotinamide (Sigma-Aldrich), 2 mM l-glutamine, 50 mM β-mercaptoethanol ...
et al. Social regulation of insulin signaling and the evolution of eusociality in ants. Science 361, 398–402 (2018). Article CAS PubMed PubMed Central Google Scholar Nässel, D. R. & Zandawala, M. Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and ...
Proinsulin: The Single Chain Precursor of Insulin AH Rubenstein,DF Steiner - 《Medical Clinics of North America》 被引量: 0发表: 1970年 Proinsulin: Single-Chain Precursor of Insulin The biosynthesis of insulin occurs in the 尾-cell via a single-chain protein, proinsulin, which is converted to...
In general, the expected specificity of insulin expression in beta cells can be recovered for all datasets when using DISCERN’s reconstruction using the smartseq2-hq reference. Conversely, the reconstruction from hq to the indrop-lq reference results in diffuse insulin expression across all ...
Physical activity has a beneficial effect on insulin sensitivity in normal as well as insulin resistant populations. A distinction should be made between t... LB Borghouts,HA Keizer - 《International Journal of Sports Medicine》 被引量: 844发表: 2000年 Short-term sprint interval training increases...
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Diabetic nephropathy (DN) is one of the major complications in diabetic patients and is the leading cause of end-stage renal disease worldwide [1]. DN is a complex disease and its progression, particularly in type 2 diabetes, is confounded by multiple pathogenic factors, such as insulin resist...
insulin expression across cell types (Additional file1: Fig. S8A left panel). This diffuse insulin expression is corrected by reconstructing the smartseq2-hq expression pattern from the indrop-lq data (Additional file1: Fig. S8A middle panel). In general, the expected specificity of insulin ...