Hence different clinical features can result depending on whether the defective gene is inherited from the mother or the father. This has been observed in two clinical syndromes associated with an imprinted region onchromosome15 (15q11-q13). Mental handicap with obesity (eg Pr...
Genes, drugs and behavior: polygenic behavioral phenotypes and single gene manipulationselevated plus-mazestress ACTHpineal glandratNo Abstract available for this article.doi:10.1007/s002130051126Klaus A. MiczekS. Barak CaineSpringer-VerlagPsychopharmacology...
Furthermore, to bridge the gap between cell type-specific APA patterns and biological functions, we combined the GWAS data to calculate the enrichment of heritability for brain-related diseases and traits. The observations showed that the altered gene regions by cell type-specific APA were ...
Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells
18). As more rat behavioral GWAS are completed, it will be possible to uncouple the role of genetics versus cocaine exposure more fully, for example, through the use of polygenic risk scores for addiction-related traits28,30,31,32,80. Consistent with previous findings showing enhanced GABA...
Which term best describes the effect of a single gene on multiple aspects of the phenotype? A. epistasis B. pleiotropy C. multiple alleles D. codominance E. polygenic inheritanceEach individual has two alleles for most traits, but not all traits. Explain why....
The gene fragments that mapped to chromosome XII are likely the paralogous Table 1 Results from the QTL analysis using the old and new maps Chr. N Markera Pos. (cM) LOD LOD thresh.b Var. expl. (%)c Female alleles Male alleles Interaction QTL interval (cM) d QTL-marker interval (cM...
We found that selected DEGs were significantly associated with immune-relevant health, milk production, and body conformation traits. Limitations and future directions Some essential marker genes are not detected in this study. These can be due to methodological noise, where a gene is expressed but ...
correction with two-sidedp-value = 0.05/number of genes (1500)). The results show that genes with heterogeneity effects across cell types are often missed in whole blood TWAS. The phenotypic effects of predicted gene expressions for other autoimmune traits are included in Supplementary Fig.7...
(c) Varying MAGMA gene window size while fixing other parameters as the default. The default version was denoted in dark blue. Error bars denote 95% confidence intervals around the mean based on meta-analysis across 20 subsampled data sets and 20 traits, using procedures as described above. ...