interpretation of accessible regions with respect to enhancer–promoter proximity, functional transcription factor binding and regulatory function. We envision that technological improvements including single-molecule, multi-omics and spatial methods will bring further insight into the secrets of genome ...
Apart from the one-way ANOVAs performed, with each simulation parameter (e.g., phase length, effect size, degree of autocorrelation) studied separately as a factor, I also performed ANOVAs with all factors simultaneously. The results are available at https://osf.io/u5nsf, but they are not...
Research based on a strategy of single-cell low-coverage whole genome sequencing (SLWGS) has enabled better reproducibility and accuracy for detection of copy number variations (CNVs). The whole genome amplification (WGA) method and sequencing platform are critical factors for successful SLWGS (<0...
J. chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data. Nat. Methods 14, 975–978 (2017). Article CAS PubMed Central PubMed Google Scholar Kartha, V. K. et al. Functional inference of gene regulation using single-cell multi-omics. Cell Genom. 2...
Methods The current study aimed to investigate whether an intervention using a digital game was effective for preserving and improving the cognitive function of residents in nursing homes. An intervention study was conducted using a single-case AB design with multiple baselines. The participants in the...
Future studies should incorporate information on managing stress in patient education, as it may be a salient factor in how patients make decisions regarding the number of embryos transferred. Studies not included but relevant to this review provided important insights on the effectiveness of ...
(1) Design a shell model based on the similarity relationships and ratios between the shell model and the full size prototype. The scaling factor used for the span was about 15:1 (Sl= 40,000 mm/2700 mm). (2) Design and make all the steel nodes based on the actual nodal load, ...
When simulating using ANSYS modal, both natural frequencies and mode participation factor (MPF) are output by the solver. The MPF is used to determine which natural frequencies are the most important for your design. A relatively high MPF means that a particular frequency may be a problem in ...
322 fibroadenoma patients with 25.3 years of follow-up proved that biopsy-confirmed fibroadenomas are a risk factor for breast cancer23. Surprisingly, our data found that endocrine resistance pathways, which could be divided into 3 functional categories, ERBB2, BCL2, and CCND1, were upregulated ...
The count-based factor analysis models were: GLM PCA using the Poisson model and the gamma-Poisson model with α = 0.05. In the figures, we show the results for the Poisson model unless otherwise indicated. We used the avagrad optimizer. We ran NewWave with 100 genes for the mini-ba...