Single-Drug TherapyThe article discusses the pros and cons of single-drug therapy and combination therapy. This study compared the combined treatment of chronic obstructive pulmonary disease (COPD) with the l...
Combination therapy has shown its promise in the clinic for enhancing the efficacy of tumor treatment. However, the dose control of multiple drugs and their non-overlapping toxicity from different drugs are still great challenge. In this work, a single model drug, paclitaxel (PTX), is used to...
Background: Itraconazole given in pulse therapy has become popular for onychomycosis treatment since it results in less plasma exposure to the drug while m... Shemer,Avner,Nathansohn,... - 《Journal of Dermatological Treatment》 被引量: 7发表: 2009年 Social, Individual & Technological Issues for...
Such approaches may in the future reduce the risk of failure in single-target and symptom-based drug discovery and therapy. 展开 关键词: network pharmacology stroke NOX4 network analysis DOI: 10.1073/pnas.1820799116 年份: 2019 收藏 引用 批量引用 报错 分享 ...
Svensson, V. et al. Power analysis of single-cell RNA-sequencing experiments. Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells....
as hepatic metabolism and/or excretion accounted for a substantial portion (i.e., more than 20% of the absorbed drug) of the elimination of aprocitentan, this study was designed to investigate the effect of moderate hepatic function impairment on the PK, safety, and tolerability of 25 mg ...
In the trial, participants who received an injection of lepodisiran had lipoprotein(a) levels reduced by the top dose as much as 96% within two weeks and maintained levels more than 94% below baseline for 48 weeks. The drug is a small interfering RNA (siRNA) therapeutic that blocks the ...
Bottles were labeled by the drug distributor with a blinded bottle number prior to distribution to sites. On the day of dosing, after participants were confirmed to be eligible, the data system identified the participant’s treatment assignment based on the treatment table. The data system then...
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking. Here, we perf
- 《Clinical Pharmacology in Drug Development》 被引量: 0发表: 2023年 A real-world pharmacovigilance study of severe cutaneous adverse reactions associated with antiepileptic drug combination therapy: data mining of FDA adver... Background The aim of this study was to evaluate the association ...