effectively captures the continuity of cell states and models the transition from low-differentiation cells to terminally differentiated cells [27]. It can be applied to a variety of tissue types and is particularly well-suited for addressing less-studied differentiation...
Informed consent was obtained from all individual participants included in the study. Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest.Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional...
has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirecti...
Ellie has established herself as a multifaceted performer, author, philanthropist, pageant winner, and recording artist. Ellie also created a nationally renowned anti-bullying campaign and 501(c)(3), Bullying: Don't Let It Get to You. She traveled the United States as a motivational speaker and...
This involves hospital stays to enable clinical monitoring and some patients consent for the use of this unique opportunity to better understand brain function. In the current study, researchers leveraged this opportunity to understand the role of neurons in the insula in mirroring the pain of ...
We introduce CellPhy, a maximum likelihood framework for inferring phylogenetic trees from somatic single-cell single-nucleotide variants. CellPhy leverages a finite-site Markov genotype model with 16 diploid states and considers amplification error and allelic dropout. We implement CellPhy into RAxML-NG...
All partici- pants provided written informed consent for involvement in the study. A screening examination was performed within 5 weeks before the start of the study and included electrocardiograms (ECG), vital signs, physical examination, laboratory testing (hematology, chemistry, urinalysis, serology,...
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requiring participants to repeat each trial of digits (i.e.,1 6or3 7 4 1) as heard on the recording provided as part of the CTOPP-2 testing materials. The Cronbach’s Alpha coefficient for this task was α = 0.83. Both digit span tasks were presented via headphones. One mark ...
The parameter n_s represented the number of outcome states which equals the length quantified by prob_state. The parameter mu_d represented the mutation probability for each target position on every cell division. The parameter d represented the number of cell divisions. Finally, the parameter p_...