lung; G, gill.bLung cell landscape of 53,605 cells from terrestrialized and freshwater lungfish. Cells are shown by Uniform Manifold Approximation and Projection and color-coded by cluster cell type. Each dot represents a cell, and different colors are associated with specific cell types. Vasc_...
Researchers have amassed vast single-cell gene expression databases to understand how the smallest details impact human biology. However, current analysis methods struggle with the large volume of data and, as a result, produce ... Cell & Microbiology Jan 8, 2025 0 8 Framework tracks 'learnin...
Single - cell organisms began to develop in the seas that covered the planet. 单细胞生物体开始在这个星球上所有的海洋里进化. 互联网 Word list identifiers are implementation - dependent single - cell values that identify word lists. 词列表识别记号是实作相依的单一单元值,指定了词的列表. ...
The Drosophila eye is a powerful model system to study the dynamics of cell differentiation, cell state transitions, cell maturation, and pattern formation. However, a high-resolution single cell genomics resource that accurately profiles all major cell
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spannin
In each cell library there are expected to be some low quality cells and empty droplets that can be identified by their low number of reads. To remove these cells, the shortlist is filtered with a quantile based threshold. This threshold is determined by ranking the cells by read count and...
Herein we introduce PARS, a method that renders intact whole-organisms transparent for imaging with single-cell resolution while preserving fluorescent and protein-based signals and tissue architecture. Our starting point, the CLARITY method (Chung et al., 2013) provided scientists with a brain-proces...
We also analyze stem cell (hPSC)-derived retinal organoids; although organoids have a very similar cellular composition at equivalent ages as the fetal retina, there are some differences in gene expression of particular cell types. Moreover, the inner retinal lamination is disrupted at more ...
Noisy gene expression is of fundamental importance to single cells, and is therefore widely studied in single-celled organisms. Extending these studies to multicellular organisms is challenging since their cells are generally not isolated, but individuals in a tissue. Cell–cell coupling via signalling...
Acinar metaplasia is an initial step in a series of events that can lead to pancreatic cancer. Here we perform single-cell RNA-sequencing of mouse pancreas during the progression from preinvasive stages to tumor formation. Using a reporter gene, we ident