Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J. Hepatol. 75, 1397–1408 (2021). Shevde, L. A. & Samant, R. S. Role of osteopo
We identified tumor-supportive networks of paracrine and autocrine signals between GBM cells, nonmalignant neuroglia and immune cells. We present cell-intrinsic and cell-extrinsic targets and a single-cell multiomics atlas of GBM under therapy....
has been extensively explored in recent years. The cells in this complex cellular ecosystem activate or suppress tumor immunity through phenotypic changes, secretion of metabolites and cell-cell communication networks. Macrophages, as the most abundant immune ...
A single-cell atlas of the tumor and immune ecosystem of human breast cancer Cell, 177 (5) (2019), pp. 1330-1345 e1318 View in ScopusGoogle Scholar [56] X. Guo, Y. Zhang, L. Zheng, C. Zheng, J. Song, Q. Zhang, et al. Global characterization of T cells in non-small-cell ...
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8, 369–380 (2005). Article CAS PubMed Google Scholar Wagner, J. et al. A single-cell atlas of the tumor and immune ecosystem of human breast cancer. Cell 177, 1330–1345 (2019)...
Squamous cell carcinoma Tumour-necrosis factor Oncogenesis Main Tumour evolution begins with the transformation of single or multiple cells that expand to form a tumour mass. Malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phe...
Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
Tumor heterogeneity presents a formidable challenge in understanding the mechanisms driving tumor progression and metastasis. The heterogeneity of hepatocellular carcinoma (HCC) in cellular level is not clear. Integration analysis of single-cell RNA sequ
For example, tumor specimen P42 (lung adenocarcinoma mixed with sarcomatoid carcinoma) and P7 revealed a strongly inflammatory micromilieu with almost 50% T cells in contrast to specimen P2, P3, and P17, which were practically T cell depleted. Fig. 1: Advanced NSCLC single-cell atlas. a ...
et al. A single-cell atlas of the tumor and immune ecosystem of human breast cancer. Cell 177, 1330–1345 (2019). Article CAS PubMed PubMed Central Google Scholar Bedard, P. L., Hansen, A. R., Ratain, M. J. & Siu, L. L. Tumour heterogeneity in the clinic. Nature 501, 355...