Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin woundsDuring wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study ...
During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study wound fibroblast diversity using single-cell RNA-sequencing. On analysis, wound fibroblasts group into twelve clusters...
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patientsCancer-distinct fibroblastLiver cancerSPARCL1Single-cell transcriptomeSingle-cell transcriptome analysis has provided detailed insights into the ecosystem of liver cancer....
Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblastsdermal papillafibroblast heterogeneityscRNA‐seqweb resourceWound﹊nduced hair follicle neogenesis (WIHN) has been an important model to study hair follicle regeneration during ...
29 reagents referenced in Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury.
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-cell transcriptomics data across six common can
we determined the interactions between immune cells and non-immune cells in high- and low-stromal tumors. We found that both CA-MSC-secreted and fibroblast-secretedCXCL12interacted with theCXCR4receptor on CD8+T and NK cells (Fig.5a, b), and we saw over-expression ofCXCL12in CA-MSCs and ...
Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeutic targets and combined treatment strategies.
Overall, differences in LR intensities between LCAMhi and LCAMlo patients supported LCAM patient stratification, and provide insight into immune cell crosstalk possibly underlying the development of the LCAM axis. Projection of bulk transcriptomic data onto scRNA-derived signatures reveals the LCAMhi ...
Kieffer, Y.et al.Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.Cancer Discov.10, 1330–1351 (2020). ArticleCASPubMedGoogle Scholar Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer - PubMed.http...