If only one loop is broken for rewiring, there are just 10 different combinations. The number rises to 135 (C210C13) when two loops are engineered. By visual inspection of the GFP structure (PDB: 2B3P) by PyMOL, we came up with 10 possible catenane designs (Supplementary Table 1, see ...
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Fig. 4: Cluster-specific gene expression reveals the relationships among the wild-type clusters. aA heatmap showing the top ten enriched genes in each cluster. Each horizontal line represents one gene and each vertical line represents one cell. Data from equal numbers (100) of cells from each ...
Genome track of PEAK1 locus showing cell type-specific chromatin accessibility of the master OCR (red) and one dependent OCR (yellow). The master OCR and the dependent OCR are the predicted LCREs of PEAK1 Full size image While the majority (66.5–87.7%) of master regions are associated ...
Genome track of PEAK1 locus showing cell type-specific chromatin accessibility of the master OCR (red) and one dependent OCR (yellow). The master OCR and the dependent OCR are the predicted LCREs of PEAK1 Full size image While the majority (66.5–87.7%) of master regions are associated ...
APOC3 in enterocytes cells in the small intestine with an average of more than 200 UMIs in a cell, we suspected that if a fraction of a certain type of cells were broken during the sample processing, cell-specific genes with high transcriptions would be released and thus contaminate all cell...
When broken, the large of the shell is a magnet for the small shards of itself, yearning for the essence of its wholeness now separate but still belonging. The cord between me and you was short, the delivery nurse said, making your separation from me traumatic. ...
The static dashed line represents the lamellipodial margin at t = 0:07. In subsequent frames, the lamellipodium remodels to form a dye-rich membrane ruffle (red arrows, 0:19, 0:21). Within seconds, numerous small vesicles form (yellow arrowheads, frames 0:22, 0:23). The corresponding...
Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present a method for the inference of enhancer-driven GRNs, called SCENIC+. SC
Pancreatic ductal adenocarcinoma (PDAC) is the most frequent and aggressive pancreatic tumor characterized by high metastatic risk and special tumor microenvironment. To comprehensively delineate the complex intra-tumoral heterogeneity and the underlying